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Chlorine in PDB 5trk: Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine
Enzymatic activity of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine
All present enzymatic activity of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine:
2.7.7.48;
2.7.7.48;
Protein crystallography data
The structure of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine, PDB code: 5trk
was solved by
S.Sheriff,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 48.79 / 2.06 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 66.500, 91.400, 232.200, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.9 / 20.3 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine
(pdb code 5trk). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine, PDB code: 5trk:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine, PDB code: 5trk:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 5trk
Go back to
Chlorine Binding Sites List in 5trk
Chlorine binding site 1 out
of 2 in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 5trk
Go back to
Chlorine Binding Sites List in 5trk
Chlorine binding site 2 out
of 2 in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with N-{3-[(Benzenecarbonyl)Amino]-4-[(4- Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine within 5.0Å range:
|
Reference:
K.Parcella,
A.Nickel,
B.R.Beno,
S.Sheriff,
C.Wan,
Y.K.Wang,
S.B.Roberts,
N.A.Meanwell,
J.F.Kadow.
Discovery and Initial Optimization of Alkoxyanthranilic Acid Derivatives As Inhibitors of Hcv NS5B Polymerase. Bioorg. Med. Chem. Lett. V. 27 295 2017.
ISSN: ESSN 1464-3405
PubMed: 27908764
DOI: 10.1016/J.BMCL.2016.11.054
Page generated: Sat Jul 12 09:04:37 2025
ISSN: ESSN 1464-3405
PubMed: 27908764
DOI: 10.1016/J.BMCL.2016.11.054
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