Chlorine in PDB 5ufu: Structure of Ampk Bound to Activator

All present enzymatic activity of Structure of Ampk Bound to Activator:
2.7.11.1;

The structure of Structure of Ampk Bound to Activator, PDB code: 5ufu was solved by M.F.Calabrese, R.G.Kurumbail, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.43 / 3.45
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	124.264, 124.264, 401.569, 90.00, 90.00, 120.00
R / Rfree (%)	19.3 / 23.8

The binding sites of Chlorine atom in the Structure of Ampk Bound to Activator (pdb code 5ufu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of Ampk Bound to Activator, PDB code: 5ufu:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Structure of Ampk Bound to Activator


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Ampk Bound to Activator within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:57.8 occ:1.00 CL A:85V602 0.0 57.8 1.0 C12 A:85V602 1.7 54.6 1.0 C11 A:85V602 2.7 54.0 1.0 C7 A:85V602 2.7 54.0 1.0 C1 A:85V602 3.1 51.5 1.0 C6 A:85V602 3.1 52.5 1.0 CD1 B:ILE115 3.7 65.8 1.0 CZ A:PHE90 3.8 56.7 1.0 CG1 B:VAL81 3.8 60.6 1.0 C10 A:85V602 4.0 54.0 1.0 CE1 A:PHE90 4.0 56.2 1.0 C8 A:85V602 4.0 54.6 1.0 CG1 B:ILE115 4.1 59.4 1.0 CG1 B:VAL113 4.2 55.6 1.0 C2 A:85V602 4.2 50.1 1.0 CD1 A:LEU18 4.3 60.2 1.0 CD1 A:ILE46 4.3 54.2 1.0 C5 A:85V602 4.3 52.0 1.0 CG2 B:VAL113 4.4 55.9 1.0 CB B:VAL113 4.4 56.1 1.0 C9 A:85V602 4.5 54.1 1.0 CG2 B:VAL81 4.7 61.7 1.0 CB B:VAL81 4.9 61.3 1.0 CG1 A:VAL11 4.9 69.4 1.0

Chlorine binding site 2 out of 4 in the Structure of Ampk Bound to Activator


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Ampk Bound to Activator within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl603 b:51.1 occ:1.00 OG A:SER97 3.4 65.3 1.0 CB A:ALA149 3.6 67.9 1.0 N A:ALA149 3.6 64.0 1.0 N A:SER97 3.6 53.6 1.0 CB A:SER97 3.8 57.0 1.0 CA A:ALA149 4.2 65.9 1.0 CB A:ASP148 4.3 59.5 1.0 CA A:SER97 4.4 53.5 1.0 CA A:VAL96 4.5 52.8 1.0 C A:VAL96 4.6 56.2 1.0 C A:ASP148 4.6 63.9 1.0 O A:TYR95 4.6 62.3 1.0 CA A:ASP148 4.6 57.2 1.0

Chlorine binding site 3 out of 4 in the Structure of Ampk Bound to Activator


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Ampk Bound to Activator within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl604 b:75.1 occ:1.00 O A:VAL24 3.4 70.4 1.0 N A:VAL24 3.5 58.3 1.0 C A:VAL24 4.1 70.6 1.0 C28 A:STU601 4.2 57.4 1.0 CA A:GLY23 4.2 51.7 1.0 CG2 A:VAL24 4.2 61.0 1.0 C26 A:STU601 4.3 53.9 1.0 CA A:VAL24 4.3 59.6 1.0 C A:GLY23 4.4 59.2 1.0 C23 A:STU601 4.5 53.8 1.0 N4 A:STU601 4.9 56.0 1.0 CB A:VAL24 4.9 61.8 1.0 O4 A:STU601 4.9 52.8 1.0

Chlorine binding site 4 out of 4 in the Structure of Ampk Bound to Activator


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of Ampk Bound to Activator within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl605 b:53.6 occ:1.00 O A:GLY210 3.8 51.1 1.0 CE1 A:PHE102 3.9 55.3 1.0 CG2 A:ILE105 3.9 46.5 1.0 CD1 A:PHE102 4.0 53.8 1.0 C A:GLY210 4.3 50.6 1.0 CB A:ILE105 4.3 46.4 1.0 CD2 A:LEU212 4.5 46.6 1.0 CB A:ALA206 4.7 38.6 1.0 N A:THR211 4.7 46.2 1.0 CA A:THR211 4.8 45.5 1.0 CZ A:PHE102 4.8 54.2 1.0 O A:PHE102 4.9 49.5 1.0 C A:THR211 4.9 49.0 1.0

E.C.Cokorinos, J.Delmore, A.R.Reyes, B.Albuquerque, R.Kjbsted, N.O.Jrgensen, J.L.Tran, A.Jatkar, K.Cialdea, R.M.Esquejo, J.Meissen, M.F.Calabrese, J.Cordes, R.Moccia, D.Tess, C.T.Salatto, T.M.Coskran, A.C.Opsahl, D.Flynn, M.Blatnik, W.Li, E.Kindt, M.Foretz, B.Viollet, J.Ward, R.G.Kurumbail, A.S.Kalgutkar, J.F.P.Wojtaszewski, K.O.Cameron, R.A.Miller. Activation of Skeletal Muscle Ampk Promotes Glucose Disposal and Glucose Lowering in Non-Human Primates and Mice. Cell Metab. V. 25 1147 2017.
ISSN: ESSN 1932-7420
PubMed: 28467931
DOI: 10.1016/J.CMET.2017.04.010