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Atomistry » Chlorine » PDB 5ufo-5up0 » 5uj2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5ufo-5up0 » 5uj2 » |
Chlorine in PDB 5uj2: Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Neta Hairpoin Loop Deletion in Complex with Gs-639476 (Diphsohate Version of Gs-9813), MN2+ and Symmetrical Primer Template 5'-AuaaauuuProtein crystallography data
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Neta Hairpoin Loop Deletion in Complex with Gs-639476 (Diphsohate Version of Gs-9813), MN2+ and Symmetrical Primer Template 5'-Auaaauuu, PDB code: 5uj2
was solved by
T.E.Edwards,
D.Fox Iii,
T.C.Appleby,
E.Murakami,
A.Rey,
M.E.Mcgrath,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5uj2:
The structure of Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Neta Hairpoin Loop Deletion in Complex with Gs-639476 (Diphsohate Version of Gs-9813), MN2+ and Symmetrical Primer Template 5'-Auaaauuu also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Neta Hairpoin Loop Deletion in Complex with Gs-639476 (Diphsohate Version of Gs-9813), MN2+ and Symmetrical Primer Template 5'-Auaaauuu
(pdb code 5uj2). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Neta Hairpoin Loop Deletion in Complex with Gs-639476 (Diphsohate Version of Gs-9813), MN2+ and Symmetrical Primer Template 5'-Auaaauuu, PDB code: 5uj2: Chlorine binding site 1 out of 1 in 5uj2Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of Hcv NS5B Genotype 2A Jfh-1 Isolate with S15G E86Q E87Q C223H V321I Mutations and DELTA8 Neta Hairpoin Loop Deletion in Complex with Gs-639476 (Diphsohate Version of Gs-9813), MN2+ and Symmetrical Primer Template 5'-Auaaauuu
![]() Mono view ![]() Stereo pair view
Reference:
T.A.Kirschberg,
S.Metobo,
M.O.Clarke,
V.Aktoudianakis,
D.Babusis,
O.Barauskas,
G.Birkus,
T.Butler,
D.Byun,
G.Chin,
E.Doerffler,
T.E.Edwards,
M.Fenaux,
R.Lee,
W.Lew,
M.R.Mish,
E.Murakami,
Y.Park,
N.H.Squires,
N.Tirunagari,
T.Wang,
M.Whitcomb,
J.Xu,
H.Yang,
H.Ye,
L.Zhang,
T.C.Appleby,
J.Y.Feng,
A.S.Ray,
A.Cho,
C.U.Kim.
Discovery of A 2'-Fluoro-2'-C-Methyl C-Nucleotide Hcv Polymerase Inhibitor and A Phosphoramidate Prodrug with Favorable Properties. Bioorg. Med. Chem. Lett. V. 27 1840 2017.
Page generated: Fri Jul 26 18:07:18 2024
ISSN: ESSN 1464-3405 PubMed: 28274633 DOI: 10.1016/J.BMCL.2017.02.037 |
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