Chlorine in PDB 5umm: Crystal Structure of Human MDM2 in Complex with 12-Mer Peptide Inhibitor M3

All present enzymatic activity of Crystal Structure of Human MDM2 in Complex with 12-Mer Peptide Inhibitor M3:
2.3.2.27;

The structure of Crystal Structure of Human MDM2 in Complex with 12-Mer Peptide Inhibitor M3, PDB code: 5umm was solved by P.Marzena, G.Neelakshi, T.William, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.95 / 1.65
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	26.567, 87.895, 36.576, 90.00, 92.30, 90.00
R / Rfree (%)	17.8 / 23.1

The binding sites of Chlorine atom in the Crystal Structure of Human MDM2 in Complex with 12-Mer Peptide Inhibitor M3 (pdb code 5umm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human MDM2 in Complex with 12-Mer Peptide Inhibitor M3, PDB code: 5umm:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human MDM2 in Complex with 12-Mer Peptide Inhibitor M3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human MDM2 in Complex with 12-Mer Peptide Inhibitor M3 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl101 b:39.0 occ:1.00 OE1 D:GLU5 3.5 34.6 1.0 NE2 B:GLN9 3.7 46.2 1.0 OE2 D:GLU5 3.8 43.4 1.0 CD D:GLU5 4.1 34.3 1.0 CD B:GLN9 4.9 43.8 1.0 CD2 D:LEU1 5.0 38.4 1.0

P.Marzena, G.Neelakshi, T.William. Design of Ultrahigh-Affinity and Dual-Specificity Peptide Antagonists of MDM2 and Mdmx For P53 Activation To Be Published.