Chlorine in PDB 5w4l: Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5.

The structure of Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5., PDB code: 5w4l was solved by W.D.Tolbert, N.Gohain, M.Pazgier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.92
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	311.018, 53.291, 223.577, 90.00, 128.89, 90.00
R / Rfree (%)	23.1 / 29.2

The binding sites of Chlorine atom in the Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5. (pdb code 5w4l). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5., PDB code: 5w4l:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5. within 5.0Å range: probe atom residue distance (Å) B Occ N:Cl101 b:54.3 occ:1.00 NE N:ARG9 3.5 63.0 1.0 O G:GLY367 3.9 51.1 1.0 NH2 N:ARG9 3.9 62.0 1.0 CZ N:ARG9 4.2 62.0 1.0 CG N:ARG9 4.4 62.8 1.0 C G:GLY367 4.4 50.2 1.0 CD N:ARG9 4.4 63.1 1.0 OD1 G:ASP368 4.6 47.8 1.0 N G:ASP368 4.9 48.3 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Non-Neutralizing and Adcc-Potent C11-Like Antibody N12-I3 in Complex with Hiv-1 Clade A/E GP120, the CD4 Mimetic M48U1, and the Antibody N5-I5. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl611 b:59.8 occ:1.00 O A:GLY367 3.3 51.3 1.0 NE M:ARG9 3.4 58.1 1.0 NH2 M:ARG9 3.7 57.5 1.0 C A:GLY367 3.8 50.3 1.0 CZ M:ARG9 4.0 58.0 1.0 CD M:ARG9 4.4 57.5 1.0 N A:ASP368 4.4 49.0 1.0 CA A:ASP368 4.5 48.2 1.0 CA A:GLY367 4.5 51.0 1.0 CG M:ARG9 4.6 57.3 1.0 OD1 A:ASP368 5.0 49.0 1.0

W.D.Tolbert, N.Gohain, N.Alsahafi, V.Van, C.Orlandi, S.Ding, L.Martin, A.Finzi, G.K.Lewis, K.Ray, M.Pazgier. Targeting the Late Stage of Hiv-1 Entry For Antibody-Dependent Cellular Cytotoxicity: Structural Basis For Env Epitopes in the C11 Region. Structure V. 25 1719 2017.
ISSN: ISSN 1878-4186
PubMed: 29056481
DOI: 10.1016/J.STR.2017.09.009