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Chlorine in PDB 5wnm: Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680)

Enzymatic activity of Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680)

All present enzymatic activity of Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680):
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680), PDB code: 5wnm was solved by C.S.Huang, S.G.Hymowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.01 / 2.60
Space group I 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 70.820, 109.612, 146.090, 90.00, 90.00, 90.00
R / Rfree (%) 22.8 / 26.4

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680) (pdb code 5wnm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680), PDB code: 5wnm:

Chlorine binding site 1 out of 1 in 5wnm

Go back to Chlorine Binding Sites List in 5wnm
Chlorine binding site 1 out of 1 in the Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Murine Receptor-Interacting Protein 4 (RIPK4) D143N Bound to Tozasertib (Vx-680) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:47.6
occ:1.00
 N A:ARG253 3.5 50.4 1.0
CA A:ARG251 3.5 53.3 1.0
C A:ARG251 3.5 52.1 1.0
NE A:ARG251 3.5 54.5 1.0
N A:ALA254 3.5 50.5 1.0
CB A:ARG253 3.6 51.1 1.0
N A:PRO252 3.8 50.6 1.0
CB A:ARG251 3.8 52.2 1.0
O A:ARG251 3.9 53.9 1.0
CD A:ARG251 3.9 52.1 1.0
CA A:ARG253 3.9 51.6 1.0
CD A:PRO252 3.9 49.7 1.0
CG A:ARG253 4.0 53.1 1.0
CB A:ALA254 4.2 50.4 1.0
C A:ARG253 4.3 52.0 1.0
C A:PRO252 4.5 51.6 1.0
CA A:ALA254 4.5 51.6 1.0
CG A:ARG251 4.5 52.9 1.0
CZ A:ARG251 4.6 59.5 1.0
CA A:PRO252 4.7 52.1 1.0
NH2 A:ARG251 4.8 59.5 1.0
N A:ARG251 4.8 56.1 1.0
CG A:PRO252 4.8 50.2 1.0
O A:PRO250 4.9 58.5 1.0

Reference:

C.S.Huang, N.Oberbeck, Y.C.Hsiao, P.Liu, A.R.Johnson, V.M.Dixit, S.G.Hymowitz. Crystal Structure of RIPK4 Reveals Dimerization-Dependent Kinase Activity. Structure V. 26 767 2018.
ISSN: ISSN 1878-4186
PubMed: 29706531
DOI: 10.1016/J.STR.2018.04.002
Page generated: Fri Jul 26 20:37:38 2024

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