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Chlorine in PDB 5x2a: Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3)

Enzymatic activity of Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3)

All present enzymatic activity of Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3):
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3), PDB code: 5x2a was solved by C.H.Yun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.49 / 1.85
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 72.185, 103.973, 87.150, 90.00, 101.40, 90.00
R / Rfree (%) 17.4 / 21.9

Other elements in 5x2a:

The structure of Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3) also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3) (pdb code 5x2a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3), PDB code: 5x2a:

Chlorine binding site 1 out of 1 in 5x2a

Go back to Chlorine Binding Sites List in 5x2a
Chlorine binding site 1 out of 1 in the Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Egfr 696-1022 T790M/V948R in Complex with Sklb(3) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1101

b:35.0
occ:1.00
 O A:VAL845 2.8 17.5 1.0
N A:PHE795 2.9 18.6 1.0
N A:PRO794 2.9 23.4 1.0
O A:LYS846 3.0 18.1 1.0
C A:MET793 3.1 23.0 1.0
CD A:PRO794 3.2 27.2 1.0
CA A:MET793 3.3 21.8 1.0
CB A:MET793 3.4 20.5 1.0
C A:LYS846 3.6 18.6 1.0
CB A:PHE795 3.6 15.3 1.0
CD2 A:PHE795 3.6 15.8 1.0
CA A:LYS846 3.6 17.8 1.0
O A:MET793 3.8 24.3 1.0
CA A:PHE795 3.8 22.7 1.0
CA A:PRO794 3.8 28.2 1.0
C A:PRO794 3.8 22.0 1.0
C A:VAL845 3.8 16.8 1.0
CE A:MET1002 3.9 25.2 1.0
CG A:PHE795 4.0 17.3 1.0
CB A:PRO794 4.1 30.2 1.0
CG A:PRO794 4.2 27.6 1.0
SD A:MET793 4.3 34.4 1.0
N A:LYS846 4.3 15.1 1.0
CG A:MET793 4.6 29.8 1.0
N A:GLY796 4.6 19.2 1.0
CE2 A:PHE795 4.7 21.4 1.0
N A:THR847 4.7 16.8 1.0
C A:PHE795 4.7 20.8 1.0
N A:MET793 4.7 20.3 1.0
CB A:LYS846 4.9 19.5 1.0
CG A:LYS846 5.0 22.5 1.0

Reference:

S.J.Zhu, P.Zhao, J.Yang, R.Ma, X.E.Yan, S.Y.Yang, J.W.Yang, C.H.Yun. Structural Insights Into Drug Development Strategy Targeting Egfr T790M/C797S. Oncotarget V. 9 13652 2018.
ISSN: ESSN 1949-2553
PubMed: 29568384
DOI: 10.18632/ONCOTARGET.24113
Page generated: Sat Jul 12 10:30:55 2025

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