Chlorine in PDB 5x2k: Crystal Structure of Egfr 696-1022 T790M in Complex with WZ4003

All present enzymatic activity of Crystal Structure of Egfr 696-1022 T790M in Complex with WZ4003:
2.7.10.1;

The structure of Crystal Structure of Egfr 696-1022 T790M in Complex with WZ4003, PDB code: 5x2k was solved by S.J.Zhu, P.Zhao, C.H.Yun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.09 / 3.20
Space group	I 2 3
Cell size a, b, c (Å), α, β, γ (°)	149.273, 149.273, 149.273, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 24.4

The binding sites of Chlorine atom in the Crystal Structure of Egfr 696-1022 T790M in Complex with WZ4003 (pdb code 5x2k). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Egfr 696-1022 T790M in Complex with WZ4003, PDB code: 5x2k:

Chlorine binding site 1 out of 1 in the Crystal Structure of Egfr 696-1022 T790M in Complex with WZ4003


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Egfr 696-1022 T790M in Complex with WZ4003 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:64.7 occ:1.00 CL5 A:0UN1101 0.0 64.7 1.0 C5 A:0UN1101 1.7 57.3 1.0 C4 A:0UN1101 2.7 55.2 1.0 C6 A:0UN1101 2.7 56.3 1.0 OBB A:0UN1101 2.8 61.0 1.0 SD A:MET790 3.7 58.6 1.0 N1 A:0UN1101 3.9 54.0 1.0 N3 A:0UN1101 3.9 57.4 1.0 CBG A:0UN1101 4.2 61.8 1.0 CB A:ALA743 4.2 41.8 1.0 C2 A:0UN1101 4.4 54.5 1.0 CE A:MET790 4.4 57.8 1.0 CD1 A:LEU844 4.4 43.4 1.0 O A:HOH1202 4.5 43.3 1.0 CB A:MET790 4.8 43.9 1.0 CG A:MET790 4.9 47.2 1.0 CG1 A:VAL726 4.9 66.6 1.0 O A:GLN791 5.0 49.4 1.0

S.J.Zhu, P.Zhao, J.Yang, R.Ma, X.E.Yan, S.Y.Yang, J.W.Yang, C.H.Yun. Structural Insights Into Drug Development Strategy Targeting Egfr T790M/C797S. Oncotarget V. 9 13652 2018.
ISSN: ESSN 1949-2553
PubMed: 29568384
DOI: 10.18632/ONCOTARGET.24113