Chlorine in PDB 5z02: Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A

All present enzymatic activity of Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A:
2.3.2.27;

The structure of Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A, PDB code: 5z02 was solved by Z.D.Su, X.Y.Cheng, R.Chen, N.Pi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.52 / 1.35
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.500, 42.990, 54.530, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 25.4

The binding sites of Chlorine atom in the Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A (pdb code 5z02). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A, PDB code: 5z02:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl101 b:18.2 occ:1.00 CL1 A:NUT101 0.0 18.2 1.0 C22 A:NUT101 1.7 17.9 1.0 C23 A:NUT101 2.7 18.5 1.0 C21 A:NUT101 2.7 18.2 1.0 CZ A:PHE65 3.7 23.9 1.0 CD1 A:ILE40 3.8 19.6 1.0 C20 A:NUT101 4.0 20.5 1.0 C24 A:NUT101 4.0 19.9 1.0 CB A:LEU36 4.1 17.9 1.0 CG2 A:ILE78 4.1 18.1 1.0 CZ A:PHE70 4.2 18.5 1.0 CE2 A:PHE70 4.2 18.6 1.0 CE1 A:PHE65 4.2 27.1 1.0 CE2 A:PHE65 4.3 30.3 1.0 CD1 A:ILE78 4.4 21.0 1.0 C19 A:NUT101 4.5 18.6 1.0 CG1 A:ILE78 4.6 17.8 1.0 CD1 A:LEU36 4.6 20.7 1.0 C A:LEU36 4.8 15.8 1.0 CG A:LEU36 4.9 18.4 1.0 N A:GLY37 4.9 16.5 1.0 O A:LEU36 5.0 16.9 1.0 CB A:ILE78 5.0 16.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl101 b:27.1 occ:1.00 CL A:NUT101 0.0 27.1 1.0 C15 A:NUT101 1.7 25.0 1.0 C16 A:NUT101 2.7 21.4 1.0 C14 A:NUT101 2.7 22.7 1.0 CE2 A:TYR79 3.4 22.3 1.0 CG A:HIS75 3.6 26.6 1.0 CZ A:TYR79 3.7 21.5 1.0 CD2 A:HIS75 3.7 27.8 1.0 CG2 A:ILE78 3.8 18.1 1.0 CD2 A:TYR79 3.8 19.8 1.0 ND1 A:HIS75 3.9 33.3 1.0 C17 A:NUT101 4.0 23.1 1.0 C13 A:NUT101 4.0 23.3 1.0 CA A:HIS75 4.0 21.5 1.0 CB A:ILE78 4.0 16.8 1.0 OH A:TYR79 4.0 28.3 1.0 CB A:HIS75 4.0 22.3 1.0 NE2 A:HIS75 4.1 34.6 1.0 CE1 A:HIS75 4.1 34.9 1.0 CD2 A:LEU33 4.2 17.4 1.0 O A:HIS75 4.3 19.3 1.0 C12 A:NUT101 4.5 20.1 1.0 CE1 A:TYR79 4.5 27.4 1.0 CG A:TYR79 4.5 17.8 1.0 CD1 A:ILE78 4.6 21.0 1.0 C A:HIS75 4.7 19.5 1.0 N A:TYR79 4.8 16.0 1.0 CD1 A:TYR79 4.8 23.6 1.0 CG1 A:ILE78 4.9 17.8 1.0 CD1 A:LEU33 4.9 18.3 1.0

Z.D.Su, X.Y.Cheng. Crystal Structure of HIS6-Tagged MDM2 with Nutlin-3A To Be Published.