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Chlorine in PDB 6ak8: Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP

Enzymatic activity of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP

All present enzymatic activity of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP:
2.7.7.7;

Protein crystallography data

The structure of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP, PDB code: 6ak8 was solved by Y.K.Chang, W.J.Wu, M.D.Tsai, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.74
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 59.750, 68.548, 110.165, 90.00, 90.00, 90.00
R / Rfree (%) 17.4 / 20.1

Other elements in 6ak8:

The structure of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP also contains other interesting chemical elements:

Calcium (Ca) 2 atoms
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP (pdb code 6ak8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP, PDB code: 6ak8:

Chlorine binding site 1 out of 1 in 6ak8

Go back to Chlorine Binding Sites List in 6ak8
Chlorine binding site 1 out of 1 in the Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Pre-Catalytic Ternary Complex of Human Dna Polymerase Mu with Templating Adenine and Incoming Ca-8OXODGTP within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl510

b:27.1
occ:1.00
 OG A:SER458 2.9 23.9 1.0
N A:SER458 3.3 20.2 1.0
O A:HOH688 3.3 26.6 1.0
C1' T:DA7 3.5 23.9 1.0
CB A:SER458 3.5 22.1 1.0
C2' T:DA7 3.5 24.1 1.0
NH2 A:ARG387 3.6 24.0 1.0
O4' T:DA7 3.6 25.2 1.0
C4' T:DA7 3.7 24.2 1.0
CB A:ASN457 3.7 20.0 1.0
CA A:SER458 3.9 20.7 1.0
CG A:ASN457 3.9 20.0 1.0
NE2 A:HIS459 3.9 33.9 1.0
CD2 A:HIS459 4.1 29.3 1.0
C3' T:DA7 4.1 24.3 1.0
ND2 A:ASN457 4.1 23.0 1.0
CE1 A:HIS459 4.2 31.4 1.0
O3' T:DA7 4.3 25.8 1.0
C A:ASN457 4.3 20.6 1.0
N A:HIS459 4.4 21.4 1.0
OD1 A:ASN457 4.4 20.7 1.0
CG A:HIS459 4.4 27.5 1.0
C A:SER458 4.4 21.5 1.0
ND1 A:HIS459 4.5 31.0 1.0
CA A:ASN457 4.5 20.2 1.0
NH2 A:ARG445 4.8 23.1 1.0
NH1 A:ARG445 4.8 22.4 1.0
CZ A:ARG387 4.8 22.3 1.0
N9 T:DA7 4.9 23.9 1.0
O2 A:EDO507 4.9 25.6 1.0
O2 T:DT6 4.9 21.8 1.0
C5' T:DA7 5.0 25.2 1.0

Reference:

Y.K.Chang, Y.P.Huang, X.X.Liu, T.P.Ko, Y.Bessho, Y.Kawano, M.Maestre-Reyna, W.J.Wu, M.D.Tsai. Human Dna Polymerase Mu Can Use A Noncanonical Mechanism For Multiple MN2+-Mediated Functions. J.Am.Chem.Soc. V. 141 8489 2019.
ISSN: ESSN 1520-5126
PubMed: 31067051
DOI: 10.1021/JACS.9B01741
Page generated: Sat Jul 12 11:25:13 2025

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