Chlorine in PDB 6baa: Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide

The binding sites of Chlorine atom in the Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide (pdb code 6baa). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide, PDB code: 6baa:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl2001 b:0.0 occ:1.00 CL1 E:GBM2001 0.0 0.0 1.0 C31 E:GBM2001 1.8 0.0 1.0 C29 E:GBM2001 2.7 0.0 1.0 C32 E:GBM2001 2.8 0.0 1.0 ND2 E:ASN437 2.9 0.1 1.0 NH1 E:ARG306 2.9 0.5 1.0 OD1 E:ASN437 3.3 0.1 1.0 CG E:ASN437 3.5 0.1 1.0 CE E:MET441 3.7 0.5 1.0 CZ E:ARG306 4.0 0.5 1.0 C27 E:GBM2001 4.0 0.0 1.0 C30 E:GBM2001 4.0 0.0 1.0 OH E:TYR377 4.4 0.8 1.0 C28 E:GBM2001 4.5 0.0 1.0 NH2 E:ARG306 4.7 0.5 1.0 SD E:MET441 4.8 0.5 1.0 NE E:ARG306 4.9 0.5 1.0 CG E:LEU592 4.9 0.0 1.0 CB E:ASN437 4.9 0.1 1.0 CD E:ARG306 4.9 0.5 1.0

Chlorine binding site 2 out of 4 in the Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl2001 b:0.0 occ:1.00 CL1 F:GBM2001 0.0 0.0 1.0 C31 F:GBM2001 1.8 0.0 1.0 C29 F:GBM2001 2.7 0.0 1.0 C32 F:GBM2001 2.8 0.0 1.0 ND2 F:ASN437 2.9 0.1 1.0 NH1 F:ARG306 2.9 0.5 1.0 OD1 F:ASN437 3.3 0.1 1.0 CG F:ASN437 3.5 0.1 1.0 CE F:MET441 3.7 0.5 1.0 CZ F:ARG306 4.0 0.5 1.0 C27 F:GBM2001 4.0 0.0 1.0 C30 F:GBM2001 4.0 0.0 1.0 OH F:TYR377 4.4 0.8 1.0 C28 F:GBM2001 4.5 0.0 1.0 NH2 F:ARG306 4.7 0.5 1.0 SD F:MET441 4.8 0.5 1.0 NE F:ARG306 4.9 0.5 1.0 CG F:LEU592 4.9 0.0 1.0 CB F:ASN437 4.9 0.1 1.0 CD F:ARG306 4.9 0.5 1.0

Chlorine binding site 3 out of 4 in the Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl2001 b:0.0 occ:1.00 CL1 G:GBM2001 0.0 0.0 1.0 C31 G:GBM2001 1.8 0.0 1.0 C29 G:GBM2001 2.7 0.0 1.0 C32 G:GBM2001 2.8 0.0 1.0 ND2 G:ASN437 2.9 0.1 1.0 NH1 G:ARG306 2.9 0.5 1.0 OD1 G:ASN437 3.3 0.1 1.0 CG G:ASN437 3.5 0.1 1.0 CE G:MET441 3.7 0.5 1.0 CZ G:ARG306 4.0 0.5 1.0 C27 G:GBM2001 4.0 0.0 1.0 C30 G:GBM2001 4.0 0.0 1.0 OH G:TYR377 4.4 0.8 1.0 C28 G:GBM2001 4.5 0.0 1.0 NH2 G:ARG306 4.7 0.5 1.0 SD G:MET441 4.8 0.5 1.0 NE G:ARG306 4.9 0.5 1.0 CG G:LEU592 4.9 0.0 1.0 CB G:ASN437 4.9 0.1 1.0 CD G:ARG306 4.9 0.5 1.0

Chlorine binding site 4 out of 4 in the Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of the Pancreatic Beta-Cell Katp Channel Bound to Atp and Glibenclamide within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl2001 b:0.0 occ:1.00 CL1 H:GBM2001 0.0 0.0 1.0 C31 H:GBM2001 1.8 0.0 1.0 C29 H:GBM2001 2.7 0.0 1.0 C32 H:GBM2001 2.8 0.0 1.0 ND2 H:ASN437 2.9 0.1 1.0 NH1 H:ARG306 2.9 0.5 1.0 OD1 H:ASN437 3.3 0.1 1.0 CG H:ASN437 3.5 0.1 1.0 CE H:MET441 3.7 0.5 1.0 CZ H:ARG306 4.0 0.5 1.0 C27 H:GBM2001 4.0 0.0 1.0 C30 H:GBM2001 4.0 0.0 1.0 OH H:TYR377 4.4 0.8 1.0 C28 H:GBM2001 4.5 0.0 1.0 NH2 H:ARG306 4.7 0.5 1.0 SD H:MET441 4.8 0.5 1.0 NE H:ARG306 4.9 0.5 1.0 CG H:LEU592 4.9 0.0 1.0 CB H:ASN437 4.9 0.1 1.0 CD H:ARG306 4.9 0.5 1.0

G.M.Martin, B.Kandasamy, F.Dimaio, C.Yoshioka, S.L.Shyng. Anti-Diabetic Drug Binding Site in A Mammalian Katpchannel Revealed By Cryo-Em. Elife V. 6 2017.
ISSN: ESSN 2050-084X
PubMed: 29035201
DOI: 10.7554/ELIFE.31054