Chlorine in PDB 6c7k: Crystal Structure of An Aco/RPE65 Chimera

All present enzymatic activity of Crystal Structure of An Aco/RPE65 Chimera:
1.13.11.75;

The structure of Crystal Structure of An Aco/RPE65 Chimera, PDB code: 6c7k was solved by P.D.Kiser, W.Shi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.84 / 2.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	119.346, 125.663, 204.412, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 21.7

The structure of Crystal Structure of An Aco/RPE65 Chimera also contains other interesting chemical elements:

Iron

(Fe)

4 atoms

The binding sites of Chlorine atom in the Crystal Structure of An Aco/RPE65 Chimera (pdb code 6c7k). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of An Aco/RPE65 Chimera, PDB code: 6c7k:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of An Aco/RPE65 Chimera


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of An Aco/RPE65 Chimera within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:58.4 occ:1.00 N C:ASP32 3.2 58.2 1.0 ND2 A:ASN341 3.2 77.5 1.0 ND2 A:ASN338 3.3 63.6 1.0 O C:ASP32 3.3 63.0 1.0 CE3 C:TRP31 3.6 55.1 1.0 CA C:TRP31 3.8 48.8 1.0 C C:ASP32 3.8 56.8 1.0 CD1 C:TYR33 3.9 61.7 1.0 C C:TRP31 4.0 54.4 1.0 CB A:ASN338 4.0 54.1 1.0 CA C:ASP32 4.1 58.7 1.0 CB C:TRP31 4.1 46.6 1.0 CG A:ASN341 4.2 68.0 1.0 CG A:ASN338 4.2 57.1 1.0 OD1 A:ASN341 4.3 74.4 1.0 CD2 C:TRP31 4.4 49.7 1.0 CZ3 C:TRP31 4.5 55.9 1.0 CB C:TYR33 4.5 53.5 1.0 O C:GLU30 4.6 55.8 1.0 CG C:TRP31 4.6 47.4 1.0 CB C:ASP32 4.6 62.6 1.0 CG C:TYR33 4.7 59.9 1.0 N C:TYR33 4.7 58.7 1.0 CE1 C:TYR33 4.8 58.8 1.0 NZ C:LYS476 4.9 81.0 1.0 CE C:LYS476 5.0 71.6 1.0 N C:TRP31 5.0 53.1 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of An Aco/RPE65 Chimera


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of An Aco/RPE65 Chimera within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:64.7 occ:1.00 ND2 B:ASN338 3.2 64.4 1.0 N D:ASP32 3.3 59.4 1.0 O D:HOH644 3.3 63.5 1.0 O D:ASP32 3.4 58.5 1.0 ND2 B:ASN341 3.5 59.8 1.0 CE3 D:TRP31 3.7 52.4 1.0 CA D:TRP31 3.8 50.2 1.0 C D:ASP32 3.9 57.3 1.0 CD1 D:TYR33 4.0 58.5 1.0 C D:TRP31 4.0 52.2 1.0 CB B:ASN338 4.1 61.1 1.0 CA D:ASP32 4.1 63.3 1.0 CG B:ASN338 4.2 65.2 1.0 CB D:TRP31 4.2 48.6 1.0 CG B:ASN341 4.4 60.6 1.0 CD2 D:TRP31 4.4 50.6 1.0 CZ3 D:TRP31 4.5 54.3 1.0 OD1 B:ASN341 4.5 63.1 1.0 O D:GLU30 4.6 59.0 1.0 CB D:TYR33 4.6 54.7 1.0 CB D:ASP32 4.7 71.2 1.0 CG D:TRP31 4.7 49.8 1.0 CG D:TYR33 4.8 60.2 1.0 N D:TYR33 4.8 54.0 1.0 CE1 D:TYR33 4.9 57.4 1.0 NZ D:LYS476 4.9 81.0 1.0

E.H.Choi, S.Suh, C.L.Sander, C.J.O.Hernandez, E.R.Bulman, N.Khadka, Z.Dong, W.Shi, K.Palczewski, P.D.Kiser. Insights Into the Pathogenesis of Dominant Retinitis Pigmentosa Associated with A D477G Mutation in RPE65. Hum.Mol.Genet. V. 27 2225 2018.
ISSN: ESSN 1460-2083
PubMed: 29659842
DOI: 10.1093/HMG/DDY128