Atomistry » Chlorine » PDB 6cof-6cub » 6ctl
Atomistry »
  Chlorine »
    PDB 6cof-6cub »
      6ctl »

Chlorine in PDB 6ctl: Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue

Enzymatic activity of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue

All present enzymatic activity of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue:
2.7.7.7;

Protein crystallography data

The structure of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue, PDB code: 6ctl was solved by V.K.Batra, S.H.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.20 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.862, 79.699, 55.119, 90.00, 107.66, 90.00
R / Rfree (%) 17.9 / 22.5

Other elements in 6ctl:

The structure of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Sodium (Na) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue (pdb code 6ctl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue, PDB code: 6ctl:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 6ctl

Go back to Chlorine Binding Sites List in 6ctl
Chlorine binding site 1 out of 2 in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl405

b:41.4
occ:1.00
 N A:HIS34 3.2 32.5 1.0
C A:ALA32 3.3 35.1 1.0
CB A:HIS34 3.3 37.3 1.0
CB A:ALA32 3.5 32.3 1.0
CA A:ALA32 3.5 37.3 1.0
N A:LYS35 3.6 27.8 1.0
N A:ILE33 3.6 36.1 1.0
O A:ALA32 3.7 35.0 1.0
CA A:HIS34 3.7 34.4 1.0
CD2 A:HIS34 3.7 35.0 1.0
CG A:HIS34 3.8 37.5 1.0
C A:HIS34 4.1 29.1 1.0
C A:ILE33 4.2 33.2 1.0
CG A:LYS35 4.3 34.1 1.0
O A:HOH648 4.5 41.8 1.0
CA A:ILE33 4.5 32.9 1.0
CB A:LYS35 4.6 33.0 1.0
CA A:LYS35 4.7 28.5 1.0
N A:ALA32 4.9 31.2 1.0
NE2 A:HIS34 5.0 39.9 1.0

Chlorine binding site 2 out of 2 in 6ctl

Go back to Chlorine Binding Sites List in 6ctl
Chlorine binding site 2 out of 2 in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl-R/S Isomers, Beta, Gamma Dttp Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl406

b:36.9
occ:0.63
 CL1 A:FDJ406 0.0 36.9 0.6
C3B A:FDJ406 1.8 26.1 1.0
PG A:FDJ406 2.9 27.2 1.0
O A:HOH704 3.0 39.6 1.0
PB A:FDJ406 3.0 26.5 1.0
O2B A:FDJ406 3.1 24.2 1.0
O3G A:FDJ406 3.2 24.6 1.0
NH2 A:ARG183 3.3 27.4 1.0
O2G A:FDJ406 3.5 25.8 1.0
O A:HOH548 3.5 36.6 1.0
O A:HOH608 3.7 23.9 1.0
O1B A:FDJ406 3.9 22.9 1.0
CB A:SER180 4.0 27.3 1.0
O3A A:FDJ406 4.1 26.9 1.0
O1G A:FDJ406 4.2 24.2 1.0
OG A:SER180 4.3 31.9 1.0
CZ A:ARG183 4.4 28.5 1.0
O A:HOH660 4.5 38.5 1.0
NH1 A:ARG183 4.6 24.7 1.0
CA A:SER180 4.9 25.3 1.0
N A:SER180 5.0 26.7 1.0

Reference:

V.K.Batra, K.Oertell, W.A.Beard, B.A.Kashemirov, C.E.Mckenna, M.F.Goodman, S.H.Wilson. Mapping Functional Substrate-Enzyme Interactions in the Pol Beta Active Site Through Chemical Biology: Structural Responses to Acidity Modification of Incoming Dntps. Biochemistry V. 57 3934 2018.
ISSN: ISSN 1520-4995
PubMed: 29874056
DOI: 10.1021/ACS.BIOCHEM.8B00418
Page generated: Sat Jul 12 12:33:21 2025

Last articles

Mg in 6ZZ6
Mg in 6ZYM
Mg in 6ZY9
Mg in 6ZY4
Mg in 6ZVH
Mg in 6ZXQ
Mg in 6ZXM
Mg in 6ZXA
Mg in 6ZXC
Mg in 6ZXF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy