Atomistry » Chlorine » PDB 6coe-6cua » 6ctt
Atomistry »
  Chlorine »
    PDB 6coe-6cua »
      6ctt »

Chlorine in PDB 6ctt: Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue

Enzymatic activity of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue

All present enzymatic activity of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue:
2.7.7.7;

Protein crystallography data

The structure of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue, PDB code: 6ctt was solved by V.K.Batra, S.H.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.48 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.825, 79.508, 55.524, 90.00, 107.67, 90.00
R / Rfree (%) 17.6 / 22.2

Other elements in 6ctt:

The structure of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Sodium (Na) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue (pdb code 6ctt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue, PDB code: 6ctt:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 6ctt

Go back to Chlorine Binding Sites List in 6ctt
Chlorine binding site 1 out of 3 in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:30.1
occ:0.60
 CL A:FF7401 0.0 30.1 0.6
C3B A:FF7401 1.8 23.5 0.6
C3B A:DJJ402 1.8 23.4 0.4
CL1 A:DJJ402 2.9 24.8 0.4
PG A:FF7401 2.9 25.6 0.6
PG A:DJJ402 2.9 25.5 0.4
PB A:FF7401 3.0 16.6 0.6
PB A:DJJ402 3.0 16.6 0.4
O1B A:FF7401 3.0 17.1 0.6
O2B A:DJJ402 3.0 17.1 0.4
O3G A:FF7401 3.1 21.9 0.6
O3G A:DJJ402 3.1 21.8 0.4
O A:HOH824 3.1 27.2 1.0
NH2 A:ARG183 3.1 17.3 1.0
O1G A:FF7401 3.5 31.1 0.6
O2G A:DJJ402 3.5 31.1 0.4
CB A:SER180 3.7 17.4 1.0
O2B A:FF7401 3.9 16.0 0.6
O1B A:DJJ402 3.9 15.9 0.4
O A:HOH684 4.0 15.9 1.0
OG A:SER180 4.1 19.7 1.0
O A:HOH688 4.1 31.9 1.0
O2G A:FF7401 4.2 22.2 0.6
O1G A:DJJ402 4.2 22.2 0.4
O3A A:FF7401 4.2 18.0 0.6
O3A A:DJJ402 4.2 17.9 0.4
CZ A:ARG183 4.3 18.1 1.0
O A:HOH732 4.3 33.0 1.0
NH1 A:ARG183 4.6 13.4 1.0
CA A:SER180 4.7 16.8 1.0
N A:SER180 4.8 16.1 1.0

Chlorine binding site 2 out of 3 in 6ctt

Go back to Chlorine Binding Sites List in 6ctt
Chlorine binding site 2 out of 3 in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl402

b:24.8
occ:0.40
 CL1 A:DJJ402 0.0 24.8 0.4
C3B A:FF7401 1.8 23.5 0.6
C3B A:DJJ402 1.8 23.4 0.4
CL A:FF7401 2.9 30.1 0.6
PG A:FF7401 2.9 25.6 0.6
PG A:DJJ402 2.9 25.5 0.4
O3A A:FF7401 3.0 18.0 0.6
O3A A:DJJ402 3.0 17.9 0.4
PB A:FF7401 3.0 16.6 0.6
PB A:DJJ402 3.0 16.6 0.4
O1G A:FF7401 3.0 31.1 0.6
O2G A:DJJ402 3.0 31.1 0.4
O A:HOH753 3.1 23.3 1.0
O A:HOH684 3.5 15.9 1.0
O2G A:FF7401 3.6 22.2 0.6
O1G A:DJJ402 3.6 22.2 0.4
O2A A:FF7401 3.6 17.6 0.6
O2A A:DJJ402 3.6 17.5 0.4
O A:HOH824 3.8 27.2 1.0
O1B A:FF7401 3.8 17.1 0.6
O2B A:DJJ402 3.8 17.1 0.4
PA A:FF7401 3.8 15.2 0.6
PA A:DJJ402 3.8 15.2 0.4
O A:HOH699 3.9 34.6 1.0
O A:HOH678 3.9 24.2 1.0
O3G A:FF7401 4.2 21.9 0.6
O3G A:DJJ402 4.2 21.8 0.4
O2B A:FF7401 4.2 16.0 0.6
O1B A:DJJ402 4.2 15.9 0.4
O1A A:FF7401 4.4 15.9 0.6
O1A A:DJJ402 4.4 15.9 0.4
O A:HOH660 4.4 26.6 1.0
MG A:MG405 5.0 14.5 1.0

Chlorine binding site 3 out of 3 in 6ctt

Go back to Chlorine Binding Sites List in 6ctt
Chlorine binding site 3 out of 3 in the Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Ternary Complex Crystal Structure of Dna Polymerase Beta with A Dideoxy Terminated Primer with Chcl (R &Amp; S Isomers, Beta, Gamma Dctp Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl406

b:31.4
occ:1.00
 OG1 A:THR297 3.0 20.9 1.0
O A:HOH796 3.1 29.4 1.0
ND2 A:ASN294 3.4 22.7 1.0
CG2 A:THR297 3.7 19.0 1.0
OD1 A:ASN294 3.9 19.6 1.0
CB A:TYR296 3.9 20.6 1.0
CB A:THR297 3.9 19.8 1.0
O T:HOH249 4.0 40.4 1.0
CG A:ASN294 4.1 19.4 1.0
CZ A:ARG299 4.1 42.4 1.0
NE A:ARG299 4.2 35.3 1.0
CD2 A:TYR296 4.2 22.1 1.0
NH2 A:ARG299 4.3 32.4 1.0
NH1 A:ARG299 4.4 40.7 1.0
CG A:TYR296 4.5 21.7 1.0
N A:THR297 4.6 17.4 1.0
O A:HOH644 4.7 20.6 1.0
CD A:ARG299 4.7 24.5 1.0
O A:HOH746 4.9 45.8 1.0
O A:HOH826 4.9 42.4 1.0
O T:HOH206 4.9 35.5 1.0
CA A:THR297 4.9 18.8 1.0

Reference:

V.K.Batra, K.Oertell, W.A.Beard, B.A.Kashemirov, C.E.Mckenna, M.F.Goodman, S.H.Wilson. Mapping Functional Substrate-Enzyme Interactions in the Pol Beta Active Site Through Chemical Biology: Structural Responses to Acidity Modification of Incoming Dntps. Biochemistry V. 57 3934 2018.
ISSN: ISSN 1520-4995
PubMed: 29874056
DOI: 10.1021/ACS.BIOCHEM.8B00418
Page generated: Sat Jul 12 12:34:25 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy