Chlorine in PDB 6ds0: Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor

The structure of Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor, PDB code: 6ds0 was solved by J.D.Mccorvy, D.Wacker, S.Wang, B.Agegnehu, J.Liu, K.Lansu, A.R.Tribo, R.H.J.Olsen, T.Che, J.Jin, B.L.Roth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.56 / 3.19
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	59.482, 120.081, 169.468, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 26.4

The binding sites of Chlorine atom in the Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor (pdb code 6ds0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor, PDB code: 6ds0:

Chlorine binding site 1 out of 1 in the Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1204 b:0.4 occ:1.00 CLAD A:H8M1204 0.0 0.4 1.0 CAS A:H8M1204 1.7 0.5 1.0 CAV A:H8M1204 2.7 85.8 1.0 CAR A:H8M1204 2.7 89.0 1.0 OAP A:H8M1204 3.0 80.8 1.0 CAL A:H8M1204 3.1 69.2 1.0 O A:HOH1301 3.2 36.5 1.0 CAZ A:H8M1204 3.5 77.2 1.0 CAB A:H8M1204 3.6 0.6 1.0 CG2 A:VAL366 3.9 84.8 1.0 CAE A:H8M1204 4.0 96.8 1.0 CAT A:H8M1204 4.0 83.4 1.0 CE1 A:PHE340 4.2 64.8 1.0 CAW A:H8M1204 4.3 77.3 1.0 CB A:LEU362 4.3 72.4 1.0 NAN A:H8M1204 4.4 77.2 1.0 CD1 A:LEU362 4.5 88.4 1.0 CAF A:H8M1204 4.5 97.7 1.0 NAM A:H8M1204 4.7 80.9 1.0 CZ A:PHE340 4.8 51.3 1.0 O A:LEU362 4.8 97.5 1.0 CG2 A:VAL208 4.9 0.9 1.0

J.D.Mccorvy, D.Wacker, S.Wang, B.Agegnehu, J.Liu, K.Lansu, A.R.Tribo, R.H.J.Olsen, T.Che, J.Jin, B.L.Roth. Structural Determinants of 5-HT2BRECEPTOR Activation and Biased Agonism. Nat. Struct. Mol. Biol. V. 25 787 2018.
ISSN: ESSN 1545-9985
PubMed: 30127358
DOI: 10.1038/S41594-018-0116-7