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Chlorine in PDB 6fgc: Crystal Structure of Gephyrin E Domain in Complex with Artesunate

Enzymatic activity of Crystal Structure of Gephyrin E Domain in Complex with Artesunate

All present enzymatic activity of Crystal Structure of Gephyrin E Domain in Complex with Artesunate:
2.10.1.1; 2.7.7.75;

Protein crystallography data

The structure of Crystal Structure of Gephyrin E Domain in Complex with Artesunate, PDB code: 6fgc was solved by V.B.Kasaragod, H.Schindelin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.55 / 1.50
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 87.100, 99.220, 113.260, 90.00, 90.00, 90.00
R / Rfree (%) 14.3 / 16.2

Other elements in 6fgc:

The structure of Crystal Structure of Gephyrin E Domain in Complex with Artesunate also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Gephyrin E Domain in Complex with Artesunate (pdb code 6fgc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Gephyrin E Domain in Complex with Artesunate, PDB code: 6fgc:

Chlorine binding site 1 out of 1 in 6fgc

Go back to Chlorine Binding Sites List in 6fgc
Chlorine binding site 1 out of 1 in the Crystal Structure of Gephyrin E Domain in Complex with Artesunate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Gephyrin E Domain in Complex with Artesunate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl817

b:39.8
occ:1.00
HG A:SER630 2.1 32.1 1.0
O A:HOH1201 2.4 33.4 0.4
OG A:SER630 2.9 26.8 1.0
O A:HOH1271 2.9 55.5 1.0
H A:GLY604 2.9 29.8 1.0
HB3 A:PRO625 3.1 26.7 1.0
HB3 A:SER630 3.1 28.2 1.0
HD2 A:PRO606 3.2 28.2 1.0
O A:HOH1063 3.3 29.6 1.0
O A:HOH1201 3.3 32.5 0.6
CB A:SER630 3.4 23.5 1.0
HB2 A:PRO625 3.4 26.7 1.0
HA2 A:GLY604 3.6 29.6 1.0
HB2 A:SER630 3.6 28.2 1.0
N A:GLY604 3.6 24.9 1.0
CB A:PRO625 3.6 22.2 1.0
HB2 A:PRO603 3.7 31.0 1.0
HD3 A:PRO606 3.7 28.2 1.0
HG2 A:PRO625 3.7 28.7 1.0
H A:LEU605 3.8 29.6 1.0
O A:HOH1264 3.8 55.2 1.0
HB3 A:ASN627 3.8 29.2 1.0
CD A:PRO606 3.8 23.5 1.0
CA A:GLY604 4.0 24.6 1.0
CG A:PRO625 4.1 23.9 1.0
HG3 A:PRO625 4.1 28.7 1.0
HG3 A:PRO606 4.2 30.1 1.0
N A:LEU605 4.3 24.7 1.0
CG A:PRO606 4.4 25.1 1.0
HG2 A:PRO606 4.4 30.1 1.0
CB A:PRO603 4.5 25.9 1.0
C A:GLY604 4.5 24.6 1.0
HB2 A:ASN627 4.6 29.2 1.0
CB A:ASN627 4.6 24.3 1.0
C A:PRO603 4.6 26.1 1.0
HB3 A:PRO603 4.6 31.0 1.0
HA A:PRO603 4.6 30.2 1.0
H A:ASN627 4.7 25.8 1.0
O A:HOH1268 4.8 41.8 0.4
CA A:PRO603 4.8 25.1 1.0
CA A:SER630 4.9 21.8 1.0
HA3 A:GLY604 4.9 29.6 1.0
O A:HOH1145 4.9 50.5 1.0
HB3 A:LEU605 5.0 35.7 1.0

Reference:

V.B.Kasaragod, T.J.Hausrat, N.Schaefer, M.Kuhn, N.R.Christensen, I.Tessmer, H.M.Maric, K.L.Madsen, C.Sotriffer, C.Villmann, M.Kneussel, H.Schindelin. Elucidating the Molecular Basis For Inhibitory Neurotransmission Regulation By Artemisinins. Neuron V. 101 673 2019.
ISSN: ISSN 1097-4199
PubMed: 30704910
DOI: 10.1016/J.NEURON.2019.01.001
Page generated: Sat Jul 12 14:01:42 2025

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