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Chlorine in PDB 6gk0: Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor

Enzymatic activity of Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor

All present enzymatic activity of Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor:
1.3.5.2;

Protein crystallography data

The structure of Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor, PDB code: 6gk0 was solved by M.Hakansson, M.J.G.W.Ladds, B.Walse, S.Lain, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.81 / 1.85
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.524, 90.524, 122.806, 90.00, 90.00, 120.00
R / Rfree (%) 16.8 / 19.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor (pdb code 6gk0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor, PDB code: 6gk0:

Chlorine binding site 1 out of 1 in 6gk0

Go back to Chlorine Binding Sites List in 6gk0
Chlorine binding site 1 out of 1 in the Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Dihydroorotate Dehydrogenase in Complex with Class III Histone Deacetylase Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl509

b:31.5
occ:1.00
OG A:SER299 2.9 19.7 1.0
NE A:ARG298 3.1 19.1 1.0
NH1 A:ARG298 3.4 20.2 1.0
CZ A:ARG298 3.8 19.7 1.0
CB A:SER299 4.0 19.5 1.0
CG A:ARG298 4.1 17.6 1.0
CD A:ARG298 4.2 17.8 1.0
O A:HOH723 4.8 31.0 1.0
O A:HOH815 4.9 39.8 1.0
N A:SER299 5.0 17.1 1.0

Reference:

M.Hakansson, M.J.G.W.Ladds, B.Walse, S.Lain. Crystal Structure of Dhodh in Complex with Inhibitor To Be Published.
Page generated: Sun Jul 28 00:00:29 2024

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