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Atomistry » Chlorine » PDB 6hvx-6hzw » 6hx1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 6hvx-6hzw » 6hx1 » |
Chlorine in PDB 6hx1: IRE1 Alpha in Complex with Imidazo[1,2-B]Pyridazin-8-Amine Compound 2Enzymatic activity of IRE1 Alpha in Complex with Imidazo[1,2-B]Pyridazin-8-Amine Compound 2
All present enzymatic activity of IRE1 Alpha in Complex with Imidazo[1,2-B]Pyridazin-8-Amine Compound 2:
2.7.11.1; Protein crystallography data
The structure of IRE1 Alpha in Complex with Imidazo[1,2-B]Pyridazin-8-Amine Compound 2, PDB code: 6hx1
was solved by
M.A.Augustin,
S.Krapp,
R.Bayliss,
I.Collins,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the IRE1 Alpha in Complex with Imidazo[1,2-B]Pyridazin-8-Amine Compound 2
(pdb code 6hx1). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the IRE1 Alpha in Complex with Imidazo[1,2-B]Pyridazin-8-Amine Compound 2, PDB code: 6hx1: Chlorine binding site 1 out of 1 in 6hx1Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the IRE1 Alpha in Complex with Imidazo[1,2-B]Pyridazin-8-Amine Compound 2
![]() Mono view ![]() Stereo pair view
Reference:
G.Colombano,
J.J.Caldwell,
T.P.Matthews,
C.Bhatia,
A.Joshi,
T.Mchardy,
N.Y.Mok,
Y.Newbatt,
L.Pickard,
J.Strover,
S.Hedayat,
M.I.Walton,
S.M.Myers,
A.M.Jones,
H.Saville,
C.Mcandrew,
R.Burke,
S.A.Eccles,
F.E.Davies,
R.Bayliss,
I.Collins.
Binding to An Unusual Inactive Kinase Conformation By Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 Alpha Kinase-Endoribonuclease. J.Med.Chem. V. 62 2447 2019.
Page generated: Sat Jul 12 15:30:06 2025
ISSN: ISSN 0022-2623 PubMed: 30779566 DOI: 10.1021/ACS.JMEDCHEM.8B01721 |
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