Chlorine in PDB 6hyx: The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C

The structure of The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C, PDB code: 6hyx was solved by H.D.Hu, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	182.810, 134.230, 160.300, 90.00, 102.09, 90.00
R / Rfree (%)	20.9 / 22.4

The structure of The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C also contains other interesting chemical elements:

Sodium

(Na)

7 atoms

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C (pdb code 6hyx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C, PDB code: 6hyx:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:58.5 occ:1.00 N A:PHE78 3.1 48.5 1.0 O A:PHE78 3.8 51.5 1.0 CB A:PHE78 3.8 50.0 1.0 CG2 A:VAL81 3.8 57.5 1.0 CA A:ARG77 3.9 46.2 1.0 CA A:PHE78 3.9 48.6 1.0 NH1 A:ARG85 3.9 56.9 1.0 CD2 A:PHE78 3.9 56.2 1.0 C A:ARG77 4.0 51.5 1.0 CB A:ARG77 4.1 45.2 1.0 N A:ARG85 4.2 79.5 1.0 CG A:ARG85 4.3 74.8 1.0 C A:PHE78 4.3 51.3 1.0 CG A:PHE78 4.4 52.7 1.0 CA A:ALA84 4.5 84.8 1.0 CG A:ARG77 4.7 47.1 1.0 CB A:ARG85 4.7 73.4 1.0 C A:ALA84 4.9 86.1 1.0 CZ A:ARG85 5.0 80.7 1.0

Chlorine binding site 2 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl402 b:63.1 occ:1.00 N B:PHE78 3.2 38.4 1.0 CD2 B:PHE78 3.6 45.6 1.0 CB B:PHE78 3.7 39.6 1.0 CG2 B:VAL81 3.7 40.4 1.0 NH1 B:ARG85 3.8 49.1 1.0 CA B:PHE78 3.9 38.1 1.0 CG B:ARG85 3.9 76.5 1.0 N B:ARG85 4.0 78.4 1.0 O B:PHE78 4.0 42.9 1.0 CA B:ARG77 4.1 37.0 1.0 C B:ARG77 4.1 42.0 1.0 CG B:PHE78 4.1 42.6 1.0 CB B:ARG85 4.4 73.8 1.0 CB B:ARG77 4.4 37.8 1.0 C B:PHE78 4.5 42.0 1.0 CA B:ALA84 4.5 81.0 1.0 CD B:ARG85 4.7 71.5 1.0 CE2 B:PHE78 4.7 49.2 1.0 C B:ALA84 4.7 84.1 1.0 CZ B:ARG85 4.8 71.4 1.0 CA B:ARG85 4.8 77.0 1.0 O B:ASN83 4.9 81.2 1.0 CB B:VAL81 4.9 39.9 1.0

Chlorine binding site 3 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl401 b:59.9 occ:1.00 N C:PHE78 3.0 53.9 1.0 CB C:PHE78 3.7 55.4 1.0 O C:PHE78 3.7 56.3 1.0 CG2 C:VAL81 3.8 57.1 1.0 CA C:PHE78 3.8 53.7 1.0 CA C:ARG77 3.9 52.5 1.0 CD2 C:PHE78 3.9 61.6 1.0 C C:ARG77 3.9 57.1 1.0 NH1 C:ARG85 4.0 59.9 1.0 CB C:ARG77 4.1 52.4 1.0 C C:PHE78 4.3 55.7 1.0 CG C:PHE78 4.3 58.4 1.0 CG C:ARG85 4.3 69.3 1.0 N C:ARG85 4.3 81.8 1.0 CA C:ALA84 4.6 86.1 1.0 CG C:ARG77 4.7 57.5 1.0 CB C:ARG85 4.8 74.0 1.0 NH1 B:ARG105 4.9 96.9 1.0 CZ C:ARG85 5.0 85.9 1.0

Chlorine binding site 4 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl401 b:61.3 occ:1.00 N D:PHE78 3.1 54.2 1.0 NH1 D:ARG85 3.7 60.0 1.0 CD2 D:PHE78 3.7 59.8 1.0 CB D:PHE78 3.8 54.9 1.0 CA D:ARG77 3.9 53.7 1.0 CG2 D:VAL81 3.9 62.1 1.0 CG D:ARG85 4.0 80.3 1.0 CA D:PHE78 4.0 53.9 1.0 C D:ARG77 4.0 57.7 1.0 O D:PHE78 4.0 59.2 1.0 N D:ARG85 4.0 87.0 1.0 CB D:ARG77 4.2 52.7 1.0 CG D:PHE78 4.2 57.3 1.0 CB D:ARG85 4.5 80.6 1.0 C D:PHE78 4.5 58.1 1.0 CA D:ALA84 4.5 89.7 1.0 CD D:ARG85 4.7 77.3 1.0 CZ D:ARG85 4.7 80.7 1.0 CG D:ARG77 4.8 59.9 1.0 CE2 D:PHE78 4.8 63.2 1.0 C D:ALA84 4.8 93.0 1.0 CA D:ARG85 4.9 85.5 1.0

Chlorine binding site 5 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Y197F-P250C within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl401 b:68.3 occ:1.00 N E:PHE78 3.3 57.7 1.0 CG2 E:VAL81 3.8 67.2 1.0 CB E:PHE78 3.9 57.6 1.0 CD2 E:PHE78 3.9 62.0 1.0 NH1 E:ARG85 4.0 68.2 1.0 O E:PHE78 4.0 61.8 1.0 N E:ARG85 4.1 85.8 1.0 CA E:PHE78 4.1 57.0 1.0 CA E:ARG77 4.1 58.2 1.0 CG E:ARG85 4.2 79.7 1.0 C E:ARG77 4.2 61.9 1.0 CB E:ARG77 4.3 61.6 1.0 CA E:ALA84 4.4 91.7 1.0 CG E:PHE78 4.4 58.9 1.0 C E:PHE78 4.5 61.8 1.0 CB E:ARG85 4.6 78.5 1.0 C E:ALA84 4.8 92.6 1.0 CG E:ARG77 4.9 74.4 1.0 O E:ASN83 4.9 95.0 1.0 CD E:ARG85 4.9 78.0 1.0 CZ E:ARG85 5.0 90.8 1.0 CA E:ARG85 5.0 83.0 1.0

H.Hu, K.Ataka, A.Menny, Z.Fourati, L.Sauguet, P.J.Corringer, P.Koehl, J.Heberle, M.Delarue. Electrostatics, Proton Sensor, and Networks Governing the Gating Transition in Glic, A Proton-Gated Pentameric Ion Channel. Proc. Natl. Acad. Sci. V. 115 12172 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30541892
DOI: 10.1073/PNAS.1813378116