Chlorine in PDB 6hzw: The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution

The structure of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution, PDB code: 6hzw was solved by H.D.Hu, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.22
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	182.416, 133.401, 160.474, 90.00, 102.48, 90.00
R / Rfree (%)	19.5 / 22

The structure of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution also contains other interesting chemical elements:

Sodium

(Na)

6 atoms

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution (pdb code 6hzw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution, PDB code: 6hzw:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:35.2 occ:1.00 O A:HOH570 2.7 40.2 1.0 O A:HOH594 3.0 47.1 1.0 N A:PHE78 3.4 26.9 1.0 NH1 A:ARG85 3.5 29.7 1.0 N A:ARG85 3.5 31.4 1.0 CD2 A:PHE78 3.7 42.6 1.0 CA A:ALA84 3.9 33.0 1.0 CB A:PHE78 4.0 30.3 1.0 CA A:ARG77 4.0 26.6 1.0 CG A:ARG85 4.0 31.8 1.0 CB A:ARG85 4.1 33.9 1.0 CD A:ARG85 4.1 32.4 1.0 C A:ARG77 4.2 26.4 1.0 CA A:PHE78 4.2 26.4 1.0 C A:ALA84 4.2 33.1 1.0 CB A:ARG77 4.3 29.1 1.0 CG2 A:VAL81 4.3 35.3 1.0 CG A:PHE78 4.3 37.0 1.0 CB A:ALA84 4.4 31.4 1.0 CA A:ARG85 4.4 31.3 1.0 O A:PHE78 4.5 25.4 1.0 CZ A:ARG85 4.6 29.5 1.0 O A:HOH562 4.6 41.2 1.0 CG A:ARG77 4.7 31.6 1.0 CE2 A:PHE78 4.7 49.4 1.0 NE A:ARG85 4.8 34.1 1.0 C A:PHE78 4.8 23.9 1.0 O A:ILE76 5.0 26.7 1.0

Chlorine binding site 2 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl405 b:49.2 occ:1.00 N A:LEU180 3.2 25.2 1.0 OD1 A:ASN139 3.3 36.3 1.0 CB A:LEU180 3.8 31.6 1.0 CA A:ARG179 3.8 29.2 1.0 C A:ARG179 3.9 27.4 1.0 CA A:LEU180 4.0 28.3 1.0 CG A:ASN139 4.0 43.1 1.0 ND2 A:ASN139 4.3 56.8 1.0 CB A:SER134 4.4 28.2 1.0 CD A:ARG179 4.4 44.3 1.0 O A:ASP178 4.4 33.4 1.0 CB A:ARG179 4.4 32.0 1.0 OG A:SER134 4.8 26.4 1.0 N A:ARG179 4.9 29.9 1.0 CG A:ARG179 4.9 37.4 1.0

Chlorine binding site 3 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl406 b:61.2 occ:1.00 N A:ALA175 3.4 24.9 1.0 CB A:ALA175 3.8 33.4 1.0 CA A:PHE174 4.2 24.3 1.0 CA A:ALA175 4.2 31.6 1.0 C A:PHE174 4.3 25.2 1.0 CB A:PHE174 4.4 27.2 1.0 O A:ALA175 4.8 26.7 1.0

Chlorine binding site 4 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl405 b:32.2 occ:1.00 O B:HOH595 2.6 28.0 1.0 NH1 B:ARG85 3.4 32.2 1.0 N B:ARG85 3.4 34.4 1.0 N B:PHE78 3.4 25.4 1.0 CD2 B:PHE78 3.6 44.9 1.0 CG B:ARG85 3.9 35.9 1.0 CA B:ALA84 3.9 39.2 1.0 CB B:PHE78 4.0 32.6 1.0 CB B:ARG85 4.0 36.1 1.0 CD B:ARG85 4.0 36.4 1.0 CA B:ARG77 4.1 26.1 1.0 C B:ALA84 4.2 37.7 1.0 C B:ARG77 4.3 25.2 1.0 CG B:PHE78 4.3 38.1 1.0 CA B:PHE78 4.3 26.3 1.0 CG2 B:VAL81 4.3 34.4 1.0 CA B:ARG85 4.3 37.4 1.0 CB B:ARG77 4.4 28.6 1.0 CB B:ALA84 4.4 30.6 1.0 CZ B:ARG85 4.5 35.3 1.0 O B:PHE78 4.6 24.6 1.0 CE2 B:PHE78 4.6 45.4 1.0 NE B:ARG85 4.7 39.5 1.0 CG B:ARG77 4.8 29.0 1.0 C B:PHE78 4.9 26.0 1.0 O B:ILE76 5.0 29.2 1.0

Chlorine binding site 5 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl406 b:33.0 occ:1.00 O C:HOH577 2.7 35.9 1.0 N C:ARG85 3.4 36.9 1.0 N C:PHE78 3.4 27.4 1.0 NH1 C:ARG85 3.5 33.1 1.0 CD2 C:PHE78 3.6 41.0 1.0 CG C:ARG85 3.9 32.2 1.0 CB C:ARG85 4.0 33.6 1.0 CB C:PHE78 4.0 30.7 1.0 CA C:ALA84 4.0 32.4 1.0 CD C:ARG85 4.0 32.8 1.0 CA C:ARG77 4.1 26.7 1.0 C C:ALA84 4.2 35.1 1.0 CA C:PHE78 4.3 27.9 1.0 C C:ARG77 4.3 27.6 1.0 CG C:PHE78 4.3 37.4 1.0 CG2 C:VAL81 4.3 36.5 1.0 CA C:ARG85 4.3 34.9 1.0 CB C:ARG77 4.3 28.8 1.0 CB C:ALA84 4.5 25.4 1.0 O C:PHE78 4.5 25.5 1.0 CZ C:ARG85 4.5 29.1 1.0 CE2 C:PHE78 4.6 43.9 1.0 CG C:ARG77 4.7 33.2 1.0 NE C:ARG85 4.7 33.7 1.0 O B:HOH550 4.9 42.2 1.0 C C:PHE78 4.9 25.3 1.0

Chlorine binding site 6 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl405 b:30.7 occ:1.00 O D:HOH581 2.6 31.9 1.0 N D:PHE78 3.4 28.1 1.0 N D:ARG85 3.5 34.9 1.0 NH1 D:ARG85 3.5 28.2 1.0 CD2 D:PHE78 3.7 40.2 1.0 CA D:ALA84 3.9 33.3 1.0 CB D:PHE78 4.0 30.6 1.0 CG D:ARG85 4.0 32.6 1.0 CA D:ARG77 4.0 26.4 1.0 CB D:ARG85 4.1 36.2 1.0 CD D:ARG85 4.1 34.9 1.0 C D:ARG77 4.2 25.8 1.0 C D:ALA84 4.2 34.8 1.0 CA D:PHE78 4.2 25.3 1.0 CB D:ARG77 4.3 25.7 1.0 CG D:PHE78 4.3 34.3 1.0 CG2 D:VAL81 4.3 30.8 1.0 CB D:ALA84 4.4 30.3 1.0 CA D:ARG85 4.4 31.9 1.0 O D:PHE78 4.5 25.7 1.0 CZ D:ARG85 4.6 31.0 1.0 CG D:ARG77 4.6 23.8 1.0 CE2 D:PHE78 4.7 42.5 1.0 NE D:ARG85 4.8 35.7 1.0 C D:PHE78 4.9 24.1 1.0 O D:ILE76 5.0 29.1 1.0

Chlorine binding site 7 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of The Glic Pentameric Ligand-Gated Ion Channel 2.22 Resolution within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl405 b:34.5 occ:1.00 O E:HOH578 2.6 38.0 1.0 NH1 E:ARG85 3.4 45.4 1.0 N E:PHE78 3.4 31.0 1.0 N E:ARG85 3.4 38.3 1.0 CD2 E:PHE78 3.6 49.8 1.0 CG E:ARG85 3.9 35.7 1.0 CA E:ALA84 4.0 38.9 1.0 CB E:PHE78 4.0 36.9 1.0 CB E:ARG85 4.0 34.9 1.0 CA E:ARG77 4.0 25.7 1.0 CD E:ARG85 4.0 36.2 1.0 C E:ARG77 4.2 27.5 1.0 C E:ALA84 4.2 39.1 1.0 CA E:PHE78 4.3 32.0 1.0 CG E:PHE78 4.3 42.5 1.0 CB E:ARG77 4.3 27.0 1.0 CA E:ARG85 4.4 35.9 1.0 CG2 E:VAL81 4.4 39.6 1.0 CB E:ALA84 4.5 32.2 1.0 CZ E:ARG85 4.5 39.9 1.0 O E:PHE78 4.5 28.6 1.0 CE2 E:PHE78 4.6 52.0 1.0 CG E:ARG77 4.6 30.1 1.0 NE E:ARG85 4.7 40.0 1.0 C E:PHE78 4.9 29.5 1.0 O E:ILE76 4.9 25.1 1.0

H.Hu, K.Ataka, A.Menny, Z.Fourati, L.Sauguet, P.J.Corringer, P.Koehl, J.Heberle, M.Delarue. Electrostatics, Proton Sensor, and Networks Governing the Gating Transition in Glic, A Proton-Gated Pentameric Ion Channel. Proc. Natl. Acad. Sci. V. 115 12172 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30541892
DOI: 10.1073/PNAS.1813378116