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Chlorine in PDB 6mep: Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
Enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437, PDB code: 6mep
was solved by
C.Da,
D.Zhang,
M.A.Stashko,
A.Cheng,
D.Hunter,
J.Norris-Drouin,
L.Graves,
M.Machius,
M.J.Miley,
D.Deryckere,
H.S.Earp,
D.K.Graham,
S.V.Frye,
X.Wang,
D.Kireev,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 37.07 / 2.89 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.366, 92.048, 69.690, 90.00, 101.67, 90.00 |
| R / Rfree (%) | 20.5 / 26.8 |
Other elements in 6mep:
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437 also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
(pdb code 6mep). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437, PDB code: 6mep:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;
In total 5 binding sites of Chlorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437, PDB code: 6mep:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;
Chlorine binding site 1 out of 5 in 6mep
Go back to
Chlorine Binding Sites List in 6mep
Chlorine binding site 1 out
of 5 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437 within 5.0Å range:
|
Chlorine binding site 2 out of 5 in 6mep
Go back to
Chlorine Binding Sites List in 6mep
Chlorine binding site 2 out
of 5 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437 within 5.0Å range:
|
Chlorine binding site 3 out of 5 in 6mep
Go back to
Chlorine Binding Sites List in 6mep
Chlorine binding site 3 out
of 5 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437 within 5.0Å range:
|
Chlorine binding site 4 out of 5 in 6mep
Go back to
Chlorine Binding Sites List in 6mep
Chlorine binding site 4 out
of 5 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437 within 5.0Å range:
|
Chlorine binding site 5 out of 5 in 6mep
Go back to
Chlorine Binding Sites List in 6mep
Chlorine binding site 5 out
of 5 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC3437 within 5.0Å range:
|
Reference:
C.Da,
D.Zhang,
M.Stashko,
E.Vasileiadi,
R.E.Parker,
K.A.Minson,
M.G.Huey,
J.M.Huelse,
D.Hunter,
T.S.K.Gilbert,
J.Norris-Drouin,
M.Miley,
L.E.Herring,
L.M.Graves,
D.Deryckere,
H.S.Earp,
D.K.Graham,
S.V.Frye,
X.Wang,
D.Kireev.
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology. J.Am.Chem.Soc. V. 141 15700 2019.
ISSN: ESSN 1520-5126
PubMed: 31497954
DOI: 10.1021/JACS.9B08660
Page generated: Sat Jul 12 16:47:26 2025
ISSN: ESSN 1520-5126
PubMed: 31497954
DOI: 10.1021/JACS.9B08660
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