Chlorine in PDB 6nyo: Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic

All present enzymatic activity of Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic:
2.3.2.23;

The structure of Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic, PDB code: 6nyo was solved by S.K.Olsen, K.M.Williams, J.H.Atkison, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.78 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.585, 55.737, 119.785, 90.00, 90.00, 90.00
R / Rfree (%)	17.5 / 20.2

The binding sites of Chlorine atom in the Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic (pdb code 6nyo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic, PDB code: 6nyo:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:16.7 occ:1.00 CL28 A:U94301 0.0 16.7 1.0 C26 A:U94301 1.8 11.4 1.0 C25 A:U94301 2.7 13.6 1.0 C27 A:U94301 2.8 14.1 1.0 CD2 A:PHE58 3.4 13.4 1.0 CE2 A:PHE58 3.4 14.0 1.0 CD1 A:TYR53 3.8 13.8 1.0 C24 A:U94301 4.0 16.8 1.0 CG A:TYR53 4.0 13.5 1.0 C22 A:U94301 4.1 12.2 1.0 CB A:TYR53 4.1 13.1 1.0 CE A:MET81 4.1 29.6 1.0 CA A:GLY47 4.1 13.6 1.0 CG A:PHE58 4.4 12.8 1.0 CZ A:PHE58 4.4 14.8 1.0 CD1 A:LEU131 4.4 13.4 1.0 CE1 A:TYR53 4.5 14.5 1.0 N A:GLY47 4.5 14.3 1.0 C23 A:U94301 4.5 14.4 1.0 CG2 A:ILE45 4.6 18.3 1.0 O A:PHE46 4.7 17.5 1.0 CD A:PRO48 4.7 14.1 1.0 C A:PHE46 4.8 15.5 1.0 CD2 A:TYR53 4.9 14.7 1.0 CD2 A:LEU131 5.0 15.3 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of A Human CDC34-Ubiquitin Thioester Mimetic within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:28.6 occ:1.00 CL29 A:U94301 0.0 28.6 1.0 C24 A:U94301 1.8 16.8 1.0 C25 A:U94301 2.7 13.6 1.0 C23 A:U94301 2.7 14.4 1.0 O A:HOH420 3.1 23.1 1.0 CG1 A:ILE128 3.7 13.4 1.0 CE1 A:PHE28 3.8 19.3 1.0 OH A:TYR190 3.8 21.8 1.0 C26 A:U94301 4.0 11.4 1.0 CG A:PRO48 4.0 15.6 1.0 CZ A:PHE28 4.0 17.8 1.0 C22 A:U94301 4.0 12.2 1.0 CG2 A:ILE128 4.2 14.2 1.0 O A:HOH450 4.3 21.7 1.0 CB A:ILE128 4.3 11.6 1.0 CD1 A:ILE128 4.3 17.8 1.0 CA E:GLY47 4.4 13.4 1.0 O A:PHE46 4.4 17.5 1.0 O E:GLY47 4.4 12.4 1.0 CD A:PRO48 4.5 14.1 1.0 C27 A:U94301 4.5 14.1 1.0 CG2 A:ILE45 4.5 18.3 1.0 CA A:ILE128 4.6 9.5 1.0 CD1 A:LEU131 4.6 13.4 1.0 CD1 A:PHE28 4.9 20.2 1.0 C E:GLY47 4.9 12.0 1.0

K.M.Williams, S.Qie, J.H.Atkison, S.Salazar-Arango, J.Alan Diehl, S.K.Olsen. Structural Insights Into E1 Recognition and the Ubiquitin-Conjugating Activity of the E2 Enzyme CDC34. Nat Commun V. 10 3296 2019.
ISSN: ESSN 2041-1723
PubMed: 31341161
DOI: 10.1038/S41467-019-11061-8