Chlorine in PDB 6od3: Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence

The structure of Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence, PDB code: 6od3 was solved by J.R.Horton, X.Cheng, J.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.90 / 1.49
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	47.180, 58.946, 62.720, 104.63, 90.34, 94.86
R / Rfree (%)	22.1 / 23.7

The binding sites of Chlorine atom in the Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence (pdb code 6od3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence, PDB code: 6od3:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl703 b:28.8 occ:1.00 O B:HOH827 3.2 43.4 1.0 O A:HOH832 3.3 37.0 1.0 NZ B:LYS607 3.4 32.1 1.0 NZ A:LYS607 3.5 36.3 1.0 CD B:LYS607 3.8 23.2 1.0 CD A:LYS607 3.9 24.9 1.0 CE2 B:PHE588 3.9 19.6 1.0 CE2 A:PHE588 4.0 17.4 1.0 CE B:LYS607 4.1 29.2 1.0 CG2 B:ILE584 4.1 17.8 1.0 CE A:LYS607 4.2 31.9 1.0 CG2 A:ILE584 4.2 21.6 1.0 O B:HOH813 4.2 41.1 1.0 O A:HOH816 4.3 32.2 1.0 CZ B:PHE588 4.5 22.4 1.0 CZ A:PHE588 4.6 20.2 1.0 CD2 B:PHE588 4.9 18.5 1.0 CD2 A:PHE588 5.0 17.4 1.0 CG B:LYS607 5.0 18.2 1.0

Chlorine binding site 2 out of 2 in the Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human TCF4 C-Terminal Bhlh Domain in Complex with 13-Bp Oligonucleotide Containing E-Box Sequence within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl701 b:22.9 occ:1.00 O F:HOH733 3.2 28.6 1.0 O E:HOH836 3.3 26.6 1.0 NZ E:LYS607 3.3 20.5 1.0 NZ F:LYS607 3.4 29.4 1.0 CD E:LYS607 3.8 22.5 1.0 CD F:LYS607 3.9 24.1 1.0 CG2 F:ILE584 4.0 18.9 1.0 CE2 E:PHE588 4.0 19.2 1.0 CE E:LYS607 4.0 21.7 1.0 CG2 E:ILE584 4.1 19.9 1.0 CE F:LYS607 4.1 26.9 1.0 CE2 F:PHE588 4.1 20.1 1.0 O Z:HOH214 4.2 25.7 1.0 O F:HOH718 4.3 22.7 1.0 CZ E:PHE588 4.7 20.1 1.0 CZ F:PHE588 4.7 20.1 1.0 CD1 F:ILE584 4.8 21.8 1.0 CD2 E:PHE588 4.9 17.0 1.0 CD1 E:ILE584 5.0 20.8 1.0

J.Yang, J.R.Horton, J.Li, Y.Huang, X.Zhang, R.M.Blumenthal, X.Cheng. Structural Basis For Preferential Binding of Human TCF4 to Dna Containing 5-Carboxylcytosine. Nucleic Acids Res. V. 47 8375 2019.
ISSN: ESSN 1362-4962
PubMed: 31081034
DOI: 10.1093/NAR/GKZ381