Chlorine in PDB 6ol6: Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab

The structure of Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab, PDB code: 6ol6 was solved by C.Weidle, M.Pancera, M.Gewe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.11 / 2.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	135.688, 95.895, 66.741, 90.00, 96.15, 90.00
R / Rfree (%)	17.1 / 23.1

The binding sites of Chlorine atom in the Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab (pdb code 6ol6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab, PDB code: 6ol6:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:60.6 occ:1.00 HA3 A:GLY106 3.4 52.4 1.0 O A:THR105 3.6 42.2 1.0 HG11 A:VAL89 3.7 40.7 1.0 O A:GLY106 3.9 51.4 1.0 HG13 A:VAL89 3.9 40.7 1.0 HE1 A:PHE91 4.2 42.1 1.0 CA A:GLY106 4.2 43.6 1.0 CG1 A:VAL89 4.2 33.9 1.0 C A:GLY106 4.3 30.9 1.0 HZ A:PHE91 4.4 41.4 1.0 HG21 A:VAL89 4.5 26.7 1.0 HG22 A:THR105 4.6 66.0 1.0 C A:THR105 4.6 39.3 1.0 OG1 A:THR108 4.7 38.8 1.0 HG22 A:VAL89 4.7 26.7 1.0 CE1 A:PHE91 4.7 35.1 1.0 HG1 A:THR108 4.7 46.5 1.0 N A:GLY106 4.9 46.5 1.0 HG12 A:VAL89 4.9 40.7 1.0 CZ A:PHE91 4.9 34.5 1.0 HA2 A:GLY106 4.9 52.4 1.0 CG2 A:VAL89 5.0 22.2 1.0 O B:GLY41 5.0 30.4 1.0

Chlorine binding site 2 out of 2 in the Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of IGLB12 Scfv in Complex with Anti-Idiotype IB2 Fab within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl201 b:62.8 occ:1.00 HH H:TYR100I 3.0 41.0 1.0 OD1 H:ASP101 3.4 38.2 1.0 OH H:TYR100I 3.6 34.2 1.0 OD2 H:ASP101 3.9 33.1 1.0 HD23 L:LEU46 3.9 29.4 1.0 HD2 H:PRO97 3.9 26.9 1.0 CG H:ASP101 3.9 27.0 1.0 H L:THR56 3.9 67.8 1.0 HE1 L:TYR49 4.0 55.4 1.0 HE1 H:TYR100I 4.0 26.0 1.0 HA L:ALA55 4.0 57.0 1.0 CE1 L:TYR49 4.3 46.2 1.0 HG22 L:THR56 4.3 74.9 1.0 HD21 L:LEU46 4.3 29.4 1.0 HB1 L:ALA55 4.4 50.7 1.0 CD2 L:LEU46 4.4 24.5 1.0 HD3 H:PRO97 4.5 26.9 1.0 CZ H:TYR100I 4.5 20.4 1.0 CD H:PRO97 4.6 22.4 1.0 CE1 H:TYR100I 4.6 21.7 1.0 HD22 L:LEU46 4.6 29.4 1.0 HB L:THR56 4.7 76.3 1.0 N L:THR56 4.7 56.5 1.0 HD1 L:TYR49 4.7 44.1 1.0 CD1 L:TYR49 4.7 36.8 1.0 CA L:ALA55 4.8 47.5 1.0 CZ L:TYR49 4.8 40.2 1.0 HG3 H:PRO97 5.0 20.8 1.0 CB L:ALA55 5.0 42.3 1.0 HB2 L:ALA55 5.0 50.7 1.0 HG2 H:PRO97 5.0 20.8 1.0

T.Bancroft, B.L.Debuysscher, C.Weidle, A.Schwartz, A.Wall, M.D.Gray, J.Feng, H.R.Steach, K.S.Fitzpatrick, M.M.Gewe, P.D.Skog, C.Doyle-Cooper, T.Ota, R.K.Strong, D.Nemazee, M.Pancera, L.Stamatatos, A.T.Mcguire, J.J.Taylor. Detection and Activation of Hiv Broadly Neutralizing Antibody Precursor B Cells Using Anti-Idiotypes. J.Exp.Med. V. 216 2331 2019.
ISSN: ESSN 1540-9538
PubMed: 31345930
DOI: 10.1084/JEM.20190164