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Chlorine in PDB 6p6v: Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir
Enzymatic activity of Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir
All present enzymatic activity of Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir:
3.4.21.98; 3.6.1.15; 3.6.4.13;
3.4.21.98; 3.6.1.15; 3.6.4.13;
Protein crystallography data
The structure of Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir, PDB code: 6p6v
was solved by
J.Timm,
C.A.Schiffer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 22.81 / 2.00 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 39.551, 60.147, 83.788, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.5 / 21.3 |
Other elements in 6p6v:
The structure of Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir also contains other interesting chemical elements:
| Fluorine | (F) | 4 atoms |
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir
(pdb code 6p6v). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir, PDB code: 6p6v:
In total only one binding site of Chlorine was determined in the Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir, PDB code: 6p6v:
Chlorine binding site 1 out of 1 in 6p6v
Go back to
Chlorine Binding Sites List in 6p6v
Chlorine binding site 1 out
of 1 in the Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Hcv NS3/4A Protease Domain of Genotype 5A in Complex with Glecaprevir within 5.0Å range:
|
Reference:
J.Timm,
K.Kosovrasti,
M.Henes,
F.Leidner,
S.Hou,
N.Kurt-Yilmaz,
C.A.Schiffer.
Molecular Mechanism of Pan-Genotypic Hcv NS3/4A Protease Inhibition By Glecaprevir and Characterization of Genotype-Specific Structural Differences To Be Published.
Page generated: Mon Jul 29 13:10:14 2024
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