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Chlorine in PDB 6pp9: Crystal Structure of Braf:MEK1 Complex

Enzymatic activity of Crystal Structure of Braf:MEK1 Complex

All present enzymatic activity of Crystal Structure of Braf:MEK1 Complex:
2.7.11.1; 2.7.12.2;

Protein crystallography data

The structure of Crystal Structure of Braf:MEK1 Complex, PDB code: 6pp9 was solved by K.Li, G.Gonzalez Del-Pino, E.Park, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.65 / 2.59
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 116.697, 116.697, 130.944, 90.00, 90.00, 120.00
R / Rfree (%) 22.1 / 24.6

Other elements in 6pp9:

The structure of Crystal Structure of Braf:MEK1 Complex also contains other interesting chemical elements:

Fluorine (F) 1 atom
Magnesium (Mg) 2 atoms
Iodine (I) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Braf:MEK1 Complex (pdb code 6pp9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Braf:MEK1 Complex, PDB code: 6pp9:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 6pp9

Go back to Chlorine Binding Sites List in 6pp9
Chlorine binding site 1 out of 2 in the Crystal Structure of Braf:MEK1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Braf:MEK1 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl803

b:79.8
occ:1.00
CE2 A:TYR472 4.0 43.6 1.0
CZ A:TYR472 4.1 43.1 1.0
OH A:TYR472 4.1 61.0 1.0
CG1 A:VAL459 4.4 52.7 1.0
CE A:MET484 4.6 50.2 1.0
CD2 A:TYR472 4.7 47.2 1.0
CE1 A:TYR472 4.7 45.9 1.0
OE1 A:GLN524 4.8 76.9 1.0

Chlorine binding site 2 out of 2 in 6pp9

Go back to Chlorine Binding Sites List in 6pp9
Chlorine binding site 2 out of 2 in the Crystal Structure of Braf:MEK1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Braf:MEK1 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl805

b:79.9
occ:1.00
O B:GLY202 4.2 52.7 1.0
CB B:LYS168 4.5 49.8 1.0
CD B:LYS168 4.5 50.5 1.0
CG B:LYS168 4.7 48.9 1.0
CB B:PHE371 4.7 44.2 1.0
CD1 B:ILE204 4.9 45.6 1.0

Reference:

E.Park, S.Rawson, K.Li, B.W.Kim, S.B.Ficarro, G.G.Pino, H.Sharif, J.A.Marto, H.Jeon, M.J.Eck. Architecture of Autoinhibited and Active Braf-MEK1-14-3-3 Complexes. Nature V. 575 545 2019.
ISSN: ESSN 1476-4687
PubMed: 31581174
DOI: 10.1038/S41586-019-1660-Y
Page generated: Sat Jul 12 18:32:59 2025

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