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Atomistry » Chlorine » PDB 6q0q-6q91 » 6q73 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 6q0q-6q91 » 6q73 » |
Chlorine in PDB 6q73: PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]MethanesulfonamideEnzymatic activity of PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]Methanesulfonamide
All present enzymatic activity of PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]Methanesulfonamide:
2.7.1.153; Protein crystallography data
The structure of PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]Methanesulfonamide, PDB code: 6q73
was solved by
M.A.Convery,
P.Rowland,
K.Down,
N.Barton,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]Methanesulfonamide
(pdb code 6q73). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]Methanesulfonamide, PDB code: 6q73: Chlorine binding site 1 out of 1 in 6q73Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the PI3K Delta in Complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]Methanesulfonamide
![]() Mono view ![]() Stereo pair view
Reference:
N.Barton,
M.Convery,
A.W.J.Cooper,
K.Down,
J.N.Hamblin,
G.Inglis,
S.Peace,
J.Rowedder,
P.Rowland,
J.A.Taylor,
N.Wellaway.
Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase Delta Through A Deconstruction and Regrowth Approach. J.Med.Chem. V. 61 11061 2018.
Page generated: Mon Jul 29 13:48:22 2024
ISSN: ISSN 0022-2623 PubMed: 30532965 DOI: 10.1021/ACS.JMEDCHEM.8B01556 |
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