|
Atomistry » Chlorine » PDB 6q9h-6qin » 6qed | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 6q9h-6qin » 6qed » |
Chlorine in PDB 6qed: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- BenzylamideEnzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- Benzylamide
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- Benzylamide:
3.4.11.18; Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- Benzylamide, PDB code: 6qed
was solved by
D.Musil,
T.Heinrich,
M.Lehmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6qed:
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- Benzylamide also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- Benzylamide
(pdb code 6qed). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- Benzylamide, PDB code: 6qed: Chlorine binding site 1 out of 1 in 6qedGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-(2-Oxo-1,2,3,4-Tetrahydro- Quinolin-6-Yl)-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro- Benzylamide
![]() Mono view ![]() Stereo pair view
Reference:
T.Heinrich,
J.Seenisamy,
B.Blume,
J.Bomke,
M.Calderini,
U.Eckert,
M.Friese-Hamim,
R.Kohl,
M.Lehmann,
B.Leuthner,
D.Musil,
F.Rohdich,
F.T.Zenke.
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (Metap-2) Inhibitors. J.Med.Chem. V. 62 5025 2019.
Page generated: Sat Jul 12 18:53:28 2025
ISSN: ISSN 0022-2623 PubMed: 30939017 DOI: 10.1021/ACS.JMEDCHEM.9B00041 |
Last articlesBr in 9R0QBr in 9J73 Br in 9BJ5 Br in 8Y72 Au in 9D33 As in 9O9I Al in 9GSG Zr in 1XC1 Zr in 6Y7P Zr in 6GNL |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |