Chlorine in PDB 6rv4: Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237

The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4 was solved by K.E.J.Rodstrom, A.C.W.Pike, W.Zhang, A.Quigley, D.Speedman, S.M.M.Mukhopadhyay, L.Shrestha, R.Chalk, S.Venkaya, S.R.Bushell, A.Tessitore, N.Burgess-Brown, C.H.Arrowsmith, A.M.Edwards, C.Bountra, E.P.Carpenter, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.16 / 3.10
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	45.100, 201.330, 238.570, 90.00, 90.00, 90.00
R / Rfree (%)	25 / 25.6

The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Potassium	(K)	8 atoms

The binding sites of Chlorine atom in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 (pdb code 6rv4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl307 b:42.0 occ:1.00 CL1 A:KKZ307 0.0 42.0 1.0 C16 A:KKZ307 1.8 40.3 1.0 C15 A:KKZ307 2.7 39.5 1.0 C17 A:KKZ307 2.8 40.3 1.0 CG2 B:ILE118 3.7 29.4 1.0 C14 A:KKZ307 4.1 39.9 1.0 C18 A:KKZ307 4.1 40.8 1.0 CG2 A:THR198 4.1 20.6 1.0 CB B:ILE118 4.1 29.2 1.0 CD1 A:LEU239 4.2 38.6 1.0 CD1 B:ILE118 4.3 37.4 1.0 CB A:THR198 4.4 20.9 1.0 CG2 A:ILE235 4.5 37.1 1.0 CA A:THR198 4.6 12.5 1.0 C13 A:KKZ307 4.6 41.1 1.0 CG1 B:ILE118 4.8 29.4 1.0 O A:THR198 4.9 17.7 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl302 b:76.1 occ:1.00 CL1 D:KKZ302 0.0 76.1 1.0 C16 D:KKZ302 1.8 75.1 1.0 C15 D:KKZ302 2.7 74.9 1.0 C17 D:KKZ302 2.8 75.1 1.0 CG2 D:ILE118 3.6 37.7 1.0 C14 D:KKZ302 4.0 75.3 1.0 C18 D:KKZ302 4.1 75.5 1.0 CB D:ILE118 4.1 36.6 1.0 CG2 C:THR198 4.1 31.5 1.0 CD1 C:LEU239 4.2 48.5 1.0 CD1 D:ILE118 4.3 41.5 1.0 CB C:THR198 4.5 32.4 1.0 CG2 C:ILE235 4.5 39.9 1.0 C13 D:KKZ302 4.6 75.6 1.0 CA C:THR198 4.6 25.6 1.0 CG1 D:ILE118 4.8 36.6 1.0 O C:THR198 4.9 29.4 1.0 CD D:PRO119 4.9 35.0 1.0 CG D:PRO119 5.0 39.3 1.0

K.E.J.Rodstrom, A.K.Kiper, W.Zhang, S.Rinne, A.C.W.Pike, M.Goldstein, L.Conrad, M.Delbeck, M.Hahn, H.Meier, M.Platzk, A.Quigley, D.Speedman, L.Shrestha, S.M.M.Mukhopadhyay, N.A.Burgess-Brown, S.J.Tucker, T.Mueller, N.Decher, E.P.Carpenter. A Unique Lower X-Gate in Task Channels Sequesters Inhibitors Within the Vestibule To Be Published.