Chlorine in PDB 6rwo: Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir

The structure of Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Magnesium	(Mg)	4 atoms
Zinc	(Zn)	8 atoms

The binding sites of Chlorine atom in the Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir (pdb code 6rwo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir, PDB code: 6rwo:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:45.4 occ:1.00 N A:TYR143 3.4 27.5 1.0 CAM A:KLQ303 3.5 26.6 1.0 CAL A:KLQ303 3.8 26.6 1.0 ND2 A:ASN117 4.0 26.8 1.0 N A:ASN117 4.0 26.8 1.0 CA A:PRO142 4.1 24.1 1.0 CB A:ASN117 4.1 26.8 1.0 CA A:TYR143 4.1 27.5 1.0 C A:PRO142 4.2 24.1 1.0 CB A:ASP116 4.4 23.4 1.0 CA A:ASN117 4.5 26.8 1.0 CBD A:KLQ303 4.5 26.6 1.0 CG A:ASN117 4.6 26.8 1.0 NBE A:KLQ303 4.7 26.6 1.0 CB A:PRO142 4.7 24.1 1.0 CD1 A:TYR143 4.7 27.5 1.0 CBC A:KLQ303 4.7 26.6 1.0 CG A:TYR143 4.8 27.5 1.0 C A:ASN117 4.8 26.8 1.0 O A:VAL141 4.9 20.8 1.0

Chlorine binding site 2 out of 2 in the Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Sivrcm Intasome (Q148/G140S) in Complex with Bictegravir within 5.0Å range: probe atom residue distance (Å) B Occ I:Cl302 b:44.3 occ:1.00 N I:TYR143 3.4 28.2 1.0 CAM I:KLQ303 3.5 25.3 1.0 CAL I:KLQ303 3.8 25.3 1.0 N I:ASN117 4.0 26.3 1.0 ND2 I:ASN117 4.0 26.3 1.0 CB I:ASN117 4.1 26.3 1.0 CA I:PRO142 4.1 23.5 1.0 CA I:TYR143 4.2 28.2 1.0 C I:PRO142 4.3 23.5 1.0 CB I:ASP116 4.4 23.8 1.0 CA I:ASN117 4.5 26.3 1.0 CBD I:KLQ303 4.5 25.3 1.0 CG I:ASN117 4.6 26.3 1.0 NBE I:KLQ303 4.7 25.3 1.0 CBC I:KLQ303 4.7 25.3 1.0 CB I:PRO142 4.7 23.5 1.0 CD1 I:TYR143 4.7 28.2 1.0 CG I:TYR143 4.8 28.2 1.0 C I:ASN117 4.8 26.3 1.0 O I:VAL141 5.0 20.9 1.0 C I:ASP116 5.0 23.8 1.0

P.Cherepanov, N.Nans, N.J.Cook. Structural Basis of Second-Generation Hiv Integrase Inhibitor Action and Viral Resistance Science 2020.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.AAY4919