Atomistry » Chlorine » PDB 6sis-6sr3 » 6sqo
Atomistry »
  Chlorine »
    PDB 6sis-6sr3 »
      6sqo »

Chlorine in PDB 6sqo: Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub

Enzymatic activity of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub

All present enzymatic activity of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub:
2.3.2.23; 2.3.2.24; 2.3.2.27;

Protein crystallography data

The structure of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub, PDB code: 6sqo was solved by H.M.Magnussen, S.F.Ahmed, D.T.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 112.00 / 1.41
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 129.709, 129.709, 70.537, 90.00, 90.00, 120.00
R / Rfree (%) 13.9 / 17.3

Other elements in 6sqo:

The structure of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub also contains other interesting chemical elements:

Zinc (Zn) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub (pdb code 6sqo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub, PDB code: 6sqo:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 6sqo

Go back to Chlorine Binding Sites List in 6sqo
Chlorine binding site 1 out of 4 in the Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl503

b:55.1
occ:1.00
N A:ILE485 3.2 24.1 1.0
O A:HOH630 3.5 55.3 1.0
CA A:MET484 3.7 26.6 1.0
NZ A:LYS466 3.9 37.9 1.0
C A:MET484 3.9 24.4 1.0
CB A:MET484 4.0 31.8 1.0
O A:ILE485 4.0 26.6 1.0
CB A:ILE485 4.1 23.0 1.0
CG A:LYS469 4.1 30.3 1.0
CA A:ILE485 4.1 21.9 1.0
CG1 A:ILE485 4.3 22.5 1.0
CE A:LYS469 4.3 35.6 1.0
CD A:LYS466 4.5 31.4 1.0
C A:ILE485 4.5 23.3 1.0
CD A:LYS469 4.5 31.7 1.0
CE A:LYS466 4.8 34.6 1.0
CB A:LYS469 4.9 25.9 1.0

Chlorine binding site 2 out of 4 in 6sqo

Go back to Chlorine Binding Sites List in 6sqo
Chlorine binding site 2 out of 4 in the Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl201

b:65.4
occ:1.00
O A:HOH622 2.8 51.0 1.0
N B:LYS4 3.3 27.4 1.0
O B:HOH388 3.3 34.8 1.0
N B:LEU3 3.4 28.1 1.0
N B:ALA2 3.5 29.7 1.0
O B:HOH355 3.9 39.4 1.0
CB B:LYS4 4.0 30.1 1.0
O B:HOH450 4.0 44.4 1.0
CA B:LEU3 4.1 28.0 1.0
C B:ALA2 4.1 26.9 1.0
CE B:LYS4 4.1 42.5 1.0
CB B:LEU3 4.1 31.4 1.0
C B:LEU3 4.2 26.8 1.0
CA B:LYS4 4.3 27.9 1.0
CA B:ALA2 4.4 28.5 1.0
CG B:LYS4 4.5 33.8 1.0
CD B:LYS4 5.0 37.2 1.0
O B:ALA2 5.0 24.2 1.0

Chlorine binding site 3 out of 4 in 6sqo

Go back to Chlorine Binding Sites List in 6sqo
Chlorine binding site 3 out of 4 in the Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl503

b:52.2
occ:1.00
O D:HOH620 3.2 60.1 1.0
N D:ILE485 3.3 24.9 1.0
NZ D:LYS466 3.7 39.5 1.0
CA D:MET484 3.9 27.6 1.0
CG D:LYS469 4.0 32.9 1.0
O D:ILE485 4.1 30.2 1.0
C D:MET484 4.1 25.4 1.0
CB D:ILE485 4.1 24.1 1.0
CB D:MET484 4.2 31.7 1.0
CA D:ILE485 4.2 24.0 1.0
CG1 D:ILE485 4.3 23.4 1.0
CD D:LYS466 4.4 35.0 1.0
CE D:LYS469 4.5 39.6 1.0
CD D:LYS469 4.6 36.0 1.0
C D:ILE485 4.6 25.9 1.0
CE D:LYS466 4.6 37.3 1.0
CB D:LYS469 4.9 28.7 1.0
O D:HOH627 4.9 47.6 1.0

Chlorine binding site 4 out of 4 in 6sqo

Go back to Chlorine Binding Sites List in 6sqo
Chlorine binding site 4 out of 4 in the Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human MDM2 Ring Domain Homodimer Bound to UBCH5B- Ub within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl201

b:71.0
occ:1.00
O E:HOH422 3.0 29.1 1.0
N E:ALA2 3.4 27.0 1.0
N E:LYS4 3.4 27.8 1.0
N E:LEU3 3.5 25.2 1.0
O E:HOH459 3.7 46.2 1.0
CG E:LYS4 3.7 38.4 1.0
CB E:LYS4 3.8 31.6 1.0
O E:HOH348 3.9 40.4 1.0
C E:ALA2 4.0 24.9 1.0
CA E:LYS4 4.2 28.1 1.0
CA E:ALA2 4.2 25.8 1.0
CA E:LEU3 4.3 28.1 1.0
CD E:LYS4 4.3 43.5 1.0
C E:LEU3 4.3 26.6 1.0
CB E:LEU3 4.5 32.2 1.0
O E:ALA2 4.9 23.6 1.0
CE E:LYS4 4.9 49.7 1.0
O D:CYS441 5.0 31.7 1.0

Reference:

H.M.Magnussen, S.F.Ahmed, G.J.Sibbet, V.A.Hristova, K.Nomura, A.K.Hock, L.J.Archibald, A.G.Jamieson, D.Fushman, K.H.Vousden, A.M.Weissman, D.T.Huang. Structural Basis For Dna Damage-Induced Phosphoregulation of MDM2 Ring Domain Nat Commun 2020.
ISSN: ESSN 2041-1723
Page generated: Sat Jul 12 19:54:31 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy