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Atomistry » Chlorine » PDB 6tdh-6tm9 » 6thp » |
Chlorine in PDB 6thp: Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic AcidEnzymatic activity of Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid
All present enzymatic activity of Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid:
3.4.24.11; Protein crystallography data
The structure of Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid, PDB code: 6thp
was solved by
N.Schiering,
C.Wiesmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6thp:
The structure of Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid
(pdb code 6thp). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid, PDB code: 6thp: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6thpGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 6thpGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the Neprilysin in Complex with the Inhibitor (R)-4-(1-Carboxy-3-(3'- Chlorobiphenyl-4-Yl)Propan-2-Ylamino)-4-Oxobutanoic Acid
![]() Mono view ![]() Stereo pair view
Reference:
N.Schiering,
C.Wiesmann.
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives As Neprilysin Inhibitors Acs Med.Chem.Lett. 2020.
Page generated: Mon Jul 29 15:27:39 2024
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.9B00578 |
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