Chlorine in PDB 6tou: Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20

The structure of Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20, PDB code: 6tou was solved by J.Hellert, F.A.Rey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.51 / 2.59
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	81.945, 81.945, 155.927, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 22.5

The structure of Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20 also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

The binding sites of Chlorine atom in the Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20 (pdb code 6tou). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20, PDB code: 6tou:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1201 b:0.7 occ:1.00 NH2 A:ARG1061 3.3 0.2 1.0 CB A:ARG1061 3.5 94.3 1.0 CG A:ARG1061 3.6 91.1 1.0 N A:ARG1061 3.7 96.8 1.0 CD A:ARG1061 3.8 94.5 1.0 CB A:PRO1059 3.9 96.4 1.0 OG A:SER1060 4.1 0.7 1.0 N A:SER1060 4.1 0.6 1.0 CA A:ARG1061 4.2 93.6 1.0 CZ A:ARG1061 4.3 99.4 1.0 O A:HOH1359 4.4 0.1 1.0 NE A:ARG1061 4.5 96.5 1.0 C A:PRO1059 4.6 98.5 1.0 CA A:PRO1059 4.6 99.1 1.0 C A:SER1060 4.6 0.9 1.0 CA A:SER1060 4.8 0.6 1.0

Chlorine binding site 2 out of 3 in the Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1202 b:0.5 occ:1.00 NZ A:LYS1103 2.9 1.0 1.0 O A:HOH1319 3.3 79.9 1.0 OG1 A:THR1085 3.5 81.9 1.0 CA A:VAL1084 3.5 77.5 1.0 C A:VAL1084 3.6 77.5 1.0 O A:HOH1318 3.7 93.0 1.0 N A:THR1085 3.7 78.6 1.0 CG A:PRO1040 3.9 98.6 1.0 CG A:LYS1103 4.1 94.2 1.0 CD A:PRO1040 4.2 97.0 1.0 CE A:LYS1103 4.2 0.4 1.0 O A:PHE1083 4.3 91.6 1.0 O A:VAL1084 4.3 77.4 1.0 CB A:VAL1084 4.3 76.3 1.0 CB A:THR1085 4.4 78.4 1.0 CA A:THR1085 4.5 75.9 1.0 N A:VAL1084 4.6 82.7 1.0 CD A:LYS1103 4.6 0.5 1.0 CG1 A:VAL1084 4.8 76.5 1.0 C A:PHE1083 4.8 86.2 1.0 O A:GLN1038 4.9 82.9 1.0 N A:PRO1040 5.0 100.0 1.0

Chlorine binding site 3 out of 3 in the Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Rabies Virus Glycoprotein pH Domain in Complex with the Scfv Fragment of Broadly Neutralizing Human Antibody RVC20 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1203 b:97.0 occ:1.00 CB A:SER79 3.4 92.5 1.0 OG A:SER79 3.5 94.1 1.0 NE2 A:GLN77 3.6 0.3 1.0 N A:HIS72 3.6 95.4 1.0 CB A:HIS72 3.7 93.2 1.0 CG A:GLN77 3.8 0.5 1.0 CA A:HIS72 3.9 95.7 1.0 N A:SER79 3.9 87.9 1.0 O A:GLN77 4.1 93.0 1.0 C A:PHE78 4.1 89.8 1.0 CD2 A:HIS72 4.1 98.0 1.0 CA A:PHE78 4.2 87.1 1.0 CD A:GLN77 4.3 0.7 1.0 CG A:HIS72 4.3 98.4 1.0 O A:SER70 4.3 96.8 1.0 CA A:SER79 4.3 88.9 1.0 C A:VAL71 4.4 95.0 1.0 C A:GLN77 4.5 90.9 1.0 C A:SER70 4.6 95.1 1.0 N A:PHE78 4.6 89.5 1.0 CA A:VAL71 4.7 91.2 1.0 O A:PHE78 4.8 93.6 1.0 CB A:SER70 4.8 0.0 1.0 N A:VAL71 4.9 91.9 1.0

J.Hellert, J.Buchrieser, F.Larrous, A.Minola, G.D.D.Melo, L.Soriaga, P.England, A.Haouz, A.Telenti, O.Schwartz, D.Corti, H.Bourhy, F.A.Rey. Structure of the Prefusion-Locking Broadly Neutralizing Antibody RVC20 Bound to the Rabies Virus Glycoprotein Nat Commun.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-020-14398-7