Chlorine in PDB 6tp5: Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase

All present enzymatic activity of Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase:
1.14.11.29;

The structure of Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase, PDB code: 6tp5 was solved by M.Myllykoski, A.Sutinen, M.K.Koski, J.P.Kallio, A.Raasakka, J.Myllyharju, R.K.Wierenga, P.Koivunen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.30 / 2.25
Space group	P 31
Cell size a, b, c (Å), α, β, γ (°)	92.079, 92.079, 129.500, 90.00, 90.00, 120.00
R / Rfree (%)	18.2 / 22.1

The structure of Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase also contains other interesting chemical elements:

Iron	(Fe)	2 atoms
Calcium	(Ca)	4 atoms

The binding sites of Chlorine atom in the Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase (pdb code 6tp5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase, PDB code: 6tp5:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl723 b:0.2 occ:1.00 N A:ILE117 3.1 61.9 1.0 N A:GLY116 3.4 74.2 1.0 CB A:GLU115 3.6 74.0 1.0 CA A:ILE117 3.8 64.8 1.0 CA A:GLU115 3.8 73.3 1.0 C A:GLU115 3.9 72.1 1.0 CG A:GLU115 3.9 84.4 1.0 C A:GLY116 4.1 70.4 1.0 CA A:GLY116 4.2 71.5 1.0 CG1 A:ILE117 4.7 65.5 1.0 C A:ILE117 4.7 65.6 1.0 CD A:GLU115 4.8 0.7 1.0 O A:GLU115 4.9 80.9 1.0 O A:ILE117 4.9 73.3 1.0 CB A:ILE117 4.9 68.7 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Transmembrane Prolyl 4-Hydroxylase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl724 b:0.9 occ:1.00 NH2 B:ARG170 3.1 0.4 1.0 N A:SER268 3.3 61.1 1.0 CA A:GLU267 3.5 77.7 1.0 CG A:GLU267 3.6 97.7 1.0 OG B:SER268 3.6 60.3 1.0 CZ B:ARG170 3.6 0.3 1.0 NH2 A:ARG170 3.6 0.8 1.0 CB A:GLU267 3.7 85.0 1.0 CB B:SER268 3.7 60.3 1.0 O B:HOH851 3.8 50.8 1.0 NH1 A:ARG170 3.9 0.6 1.0 NH1 B:ARG170 3.9 0.6 1.0 C A:GLU267 3.9 66.8 1.0 OG A:SER268 4.2 72.5 1.0 CZ A:ARG170 4.2 0.0 1.0 CB A:SER268 4.3 68.5 1.0 CA A:SER268 4.4 64.6 1.0 O A:ALA266 4.5 82.4 1.0 NE B:ARG170 4.5 0.7 1.0 CD1 A:LEU174 4.6 87.5 1.0 N A:GLU267 4.7 64.9 1.0 O A:HOH847 4.7 73.2 1.0 N B:SER268 4.9 60.2 1.0 CD2 A:LEU174 4.9 81.7 1.0 CA B:SER268 4.9 65.2 1.0 CD A:GLU267 5.0 0.0 1.0

M.Myllykoski, A.Sutinen, M.K.Koski, J.Kallio, A.Raasakka, J.Myllyharju, R.Wierenga, P.Koivunen. Structure of Transmembrane Prolyl 4-Hydroxylase Reveals Unique Organization of Ef and Dioxygenase Domains J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X