Chlorine in PDB 6uyh: Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp

The structure of Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp, PDB code: 6uyh was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.66 / 1.75
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	157.290, 66.540, 112.560, 90.00, 101.74, 90.00
R / Rfree (%)	15.4 / 18

The structure of Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Bromine	(Br)	2 atoms

The binding sites of Chlorine atom in the Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp (pdb code 6uyh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp, PDB code: 6uyh:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:29.2 occ:1.00 CL1 A:HFG602 0.0 29.2 1.0 C6 A:HFG602 1.7 21.5 1.0 C5 A:HFG602 2.7 20.5 1.0 C7 A:HFG602 2.7 23.4 1.0 BR1 A:HFG602 3.3 38.3 1.0 CG A:PRO110 3.6 23.7 1.0 O A:HOH704 3.8 38.4 1.0 O A:HOH1041 3.8 27.8 1.0 CB A:PHE87 3.9 32.1 1.0 C10 A:HFG602 4.0 22.3 1.0 C8 A:HFG602 4.0 22.3 1.0 CG2 A:VAL91 4.1 26.3 1.0 CD1 A:LEU77 4.2 25.9 1.0 CB A:PRO110 4.2 24.7 1.0 C9 A:HFG602 4.5 23.1 1.0 CG A:LEU77 4.5 36.3 1.0 CG A:PHE87 4.6 34.8 1.0 CD2 A:PHE87 4.7 38.4 1.0 O A:PHE87 4.9 34.9 1.0 CD2 A:LEU77 4.9 27.4 1.0 CD A:PRO110 5.0 19.0 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl704 b:27.9 occ:1.00 CL1 B:HFG704 0.0 27.9 1.0 C6 B:HFG704 1.7 18.9 1.0 C5 B:HFG704 2.7 16.5 1.0 C7 B:HFG704 2.7 25.2 1.0 BR1 B:HFG704 3.3 40.2 1.0 CG B:PRO110 3.6 21.9 1.0 O B:HOH1191 3.8 54.5 1.0 O B:HOH1126 3.8 27.6 1.0 CB B:PHE87 3.9 41.9 1.0 C10 B:HFG704 4.0 18.3 1.0 CG2 B:VAL91 4.0 26.6 1.0 O B:HOH831 4.0 46.9 1.0 C8 B:HFG704 4.0 21.5 1.0 CD1 B:LEU77 4.1 28.3 1.0 CB B:PRO110 4.2 22.5 1.0 C9 B:HFG704 4.5 19.6 1.0 CG B:PHE87 4.6 45.7 1.0 CG B:LEU77 4.7 33.8 1.0 CD2 B:PHE87 4.7 49.5 1.0 CD2 B:LEU77 4.8 36.2 1.0 CD B:PRO110 4.9 21.4 1.0 O B:PHE87 5.0 38.8 1.0

D.M.Dranow, J.Abendroth, D.D.Lorimer, P.S.Horanyi, T.E.Edwards. Crystal Structure of Prolyl-Trna Synthetase From Naegleria Fowleri in Complex with Halofuginone and Amppnp To Be Published.