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Atomistry » Chlorine » PDB 6vck-6vkd » 6vei | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 6vck-6vkd » 6vei » |
Chlorine in PDB 6vei: Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) InhibitorEnzymatic activity of Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) Inhibitor
All present enzymatic activity of Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) Inhibitor:
1.1.1.42; Protein crystallography data
The structure of Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) Inhibitor, PDB code: 6vei
was solved by
A.Padyana,
L.Jin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6vei:
The structure of Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) Inhibitor also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) Inhibitor
(pdb code 6vei). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) Inhibitor, PDB code: 6vei: Chlorine binding site 1 out of 1 in 6veiGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Cytosolic Isocitrate Dehydrogenase (IDH1) R132H Mutant in Complex with Nadph and Ag-881 (Vorasidenib) Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
Z.Konteatis,
E.Artin,
B.Nicolay,
K.Straley,
A.K.Padyana,
L.Jin,
Y.Chen,
R.Narayaraswamy,
S.Tong,
F.Wang,
D.Zhou,
D.Cui,
Z.Cai,
Z.Luo,
C.Fang,
H.Tang,
X.Lv,
R.Nagaraja,
H.Yang,
S.M.Su,
Z.Sui,
L.Dang,
K.Yen,
J.Popovici-Muller,
P.Codega,
C.Campos,
I.K.Mellinghoff,
S.Biller.
Vorasidenib (Ag-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 For Treatment of Glioma Acs Med.Chem.Lett. 2020.
Page generated: Mon Jul 29 16:16:04 2024
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.9B00509 |
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