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Atomistry » Chlorine » PDB 6vke-6vww » 6vn2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 6vke-6vww » 6vn2 » |
Chlorine in PDB 6vn2: USP7 in Complex with Ligand Compound 18Enzymatic activity of USP7 in Complex with Ligand Compound 18
All present enzymatic activity of USP7 in Complex with Ligand Compound 18:
3.4.19.12; Protein crystallography data
The structure of USP7 in Complex with Ligand Compound 18, PDB code: 6vn2
was solved by
P.R.Leger,
D.J.Wustrow,
D.X.Hu,
S.Krapp,
K.Maskos,
M.Blaesse,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the USP7 in Complex with Ligand Compound 18
(pdb code 6vn2). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the USP7 in Complex with Ligand Compound 18, PDB code: 6vn2: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6vn2Go back to![]() ![]()
Chlorine binding site 1 out
of 2 in the USP7 in Complex with Ligand Compound 18
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 6vn2Go back to![]() ![]()
Chlorine binding site 2 out
of 2 in the USP7 in Complex with Ligand Compound 18
![]() Mono view ![]() Stereo pair view
Reference:
P.R.Leger,
D.X.Hu,
B.Biannic,
M.Bui,
X.Han,
E.Karbarz,
J.Maung,
A.Okano,
M.Osipov,
G.M.Shibuya,
K.Young,
C.Higgs,
B.Abraham,
D.Bradford,
C.Cho,
C.Colas,
S.Jacobson,
Y.M.Ohol,
D.Pookot,
P.Rana,
J.Sanchez,
N.Shah,
M.Sun,
S.Wong,
D.G.Brockstedt,
P.D.Kassner,
J.B.Schwarz,
D.J.Wustrow.
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with in Vivo Anti-Tumor Activity. J.Med.Chem. 2020.
Page generated: Mon Jul 29 16:24:22 2024
ISSN: ISSN 0022-2623 PubMed: 32302140 DOI: 10.1021/ACS.JMEDCHEM.0C00245 |
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