Chlorine in PDB 6wic: Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate

Enzymatic activity of Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate

All present enzymatic activity of Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate:
2.7.7.7;

Protein crystallography data

The structure of Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate, PDB code: 6wic was solved by A.M.Kaminski, T.A.Kunkel, L.C.Pedersen, K.Bebenek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	34.88 / 1.55
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	60.134, 62.233, 118.054, 90.00, 90.00, 90.00
*R / R_free (%)*	16.6 / 17.9

Other elements in 6wic:

The structure of Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Potassium	(K)	1 atom
Sodium	(Na)	1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate (pdb code 6wic). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate, PDB code: 6wic:

Chlorine binding site 1 out of 1 in 6wic

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Chlorine Binding Sites List in 6wic

Chlorine binding site 1 out of 1 in the Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Pre-Catalytic Quaternary Complex of Human Polymerase Mu on A Complementary Dna Double-Strand Break Substrate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl706 b:18.7 occ:0.91	OG	A:SER458	3.0	16.0	0.4
	OG	A:SER458	3.3	17.1	0.6
	O	P:HOH116	3.3	23.1	1.0
	N	A:SER458	3.4	14.9	0.6
	N	A:SER458	3.4	15.0	0.4
	CB	A:SER458	3.4	16.6	0.6
	NH2	A:ARG387	3.4	16.0	1.0
	CB	A:SER458	3.5	15.9	0.4
	O2	T:DT6	3.6	15.3	1.0
	NH2	A:ARG445	3.6	14.6	1.0
	C1'	U:DA1	3.6	15.0	1.0
	NH1	A:ARG445	3.7	15.6	1.0
	CB	A:ASN457	3.9	14.8	1.0
	O	A:HOH965	4.0	19.9	1.0
	CA	A:SER458	4.0	14.7	0.6
	CZ	A:ARG445	4.0	15.4	1.0
	CA	A:SER458	4.1	14.8	0.4
	O4'	U:DA1	4.1	16.3	1.0
	C2'	U:DA1	4.2	15.3	1.0
	CZ	A:ARG387	4.4	14.8	1.0
	C	A:ASN457	4.4	14.8	1.0
	CA	A:ASN457	4.4	13.2	1.0
	NH1	A:ARG387	4.5	15.3	1.0
	N9	U:DA1	4.6	14.0	1.0
	C2	P:DA4	4.6	13.6	1.0
	N3	U:DA1	4.6	16.4	1.0
	CG	A:ASN457	4.6	14.3	1.0
	C2	T:DT6	4.8	14.0	1.0
	C4	U:DA1	4.9	14.6	1.0
	C4'	U:DA1	5.0	15.8	1.0

Reference:

A.M.Kaminski, J.M.Pryor, D.A.Ramsden, T.A.Kunkel, L.C.Pedersen, K.Bebenek. Structural Snapshots of Human Dna Polymerase Mu Engaged on A Dna Double-Strand Break. Nat Commun V. 11 4784 2020.
ISSN: ESSN 2041-1723
PubMed: 32963245
DOI: 10.1038/S41467-020-18506-5

Page generated: Mon Jul 29 16:45:11 2024

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