Chlorine in PDB 6wmn: Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases

Enzymatic activity of Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases

All present enzymatic activity of Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases:
2.4.1.149;

Protein crystallography data

The structure of Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases, PDB code: 6wmn was solved by R.Kadirvelraj, Z.A.Wood, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	44.07 / 2.04
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	67.210, 79.810, 157.790, 90.00, 97.89, 90.00
*R / R_free (%)*	21.8 / 23.2

Other elements in 6wmn:

The structure of Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases also contains other interesting chemical elements:

Magnesium

(Mg)

4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases (pdb code 6wmn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases, PDB code: 6wmn:

Chlorine binding site 1 out of 1 in 6wmn

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Chlorine Binding Sites List in 6wmn

Chlorine binding site 1 out of 1 in the Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Poly-N-Acetyl-Lactosamine Synthase Structure Demonstrates A Modular Assembly of Catalytic Subsites For Gt-A Glycosyltransferases within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Cl407 b:57.4 occ:1.00	N	C:ILE73	3.1	78.5	1.0
	N	C:PRO72	3.4	69.2	1.0
	CD	C:PRO72	3.4	69.3	1.0
	C	C:ASN71	3.5	69.3	1.0
	CA	C:ASN71	3.6	66.8	1.0
	N	C:LEU74	3.6	82.2	1.0
	CB	C:ILE73	3.7	85.4	1.0
	CA	C:ILE73	3.8	83.7	1.0
	CG	C:LEU74	4.0	83.3	1.0
	CD1	C:LEU74	4.0	78.1	1.0
	C	C:PRO72	4.1	76.4	1.0
	CG1	C:ILE73	4.1	86.6	1.0
	CB	C:ASN71	4.1	66.7	1.0
	CA	C:PRO72	4.2	71.7	1.0
	C	C:ILE73	4.3	83.8	1.0
	O	C:ASN71	4.3	69.7	1.0
	CB	C:LEU74	4.5	77.1	1.0
	CG	C:PRO72	4.5	70.9	1.0
	CD1	C:ILE73	4.6	89.8	1.0
	CB	C:PRO72	4.6	73.4	1.0
	CA	C:LEU74	4.7	83.2	1.0
	OD1	C:ASN71	4.7	68.4	1.0
	N	C:ASN71	4.9	61.8	1.0
	CG	C:ASN71	4.9	65.5	1.0
	CG2	C:ILE73	5.0	90.3	1.0
	O	C:TYR70	5.0	66.7	1.0

Reference:

R.Kadirvelraj, J.Y.Yang, H.W.Kim, J.H.Sanders, K.W.Moremen, Z.A.Wood. Comparison of Human Poly-N-Acetyl-Lactosamine Synthase Structure with Gt-A Fold Glycosyltransferases Supports A Modular Assembly of Catalytic Subsites. J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X
PubMed: 33229435
DOI: 10.1074/JBC.RA120.015305

Page generated: Sat Jul 12 21:18:38 2025

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