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Chlorine in PDB 6wp3: Pyruvate Kinase M2 Mutant-K433Q

Enzymatic activity of Pyruvate Kinase M2 Mutant-K433Q

All present enzymatic activity of Pyruvate Kinase M2 Mutant-K433Q:
2.7.1.40;

Protein crystallography data

The structure of Pyruvate Kinase M2 Mutant-K433Q, PDB code: 6wp3 was solved by S.Nandi, M.Razzaghi, D.Srivastava, M.Dey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.11 / 1.84
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 112.378, 94.226, 109.638, 90.00, 94.80, 90.00
R / Rfree (%) 20.3 / 23

Other elements in 6wp3:

The structure of Pyruvate Kinase M2 Mutant-K433Q also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Potassium (K) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Pyruvate Kinase M2 Mutant-K433Q (pdb code 6wp3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Pyruvate Kinase M2 Mutant-K433Q, PDB code: 6wp3:

Chlorine binding site 1 out of 1 in 6wp3

Go back to Chlorine Binding Sites List in 6wp3
Chlorine binding site 1 out of 1 in the Pyruvate Kinase M2 Mutant-K433Q


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Pyruvate Kinase M2 Mutant-K433Q within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl608

b:59.6
occ:1.00
ND2 B:ASN523 3.2 35.4 1.0
CG B:ASN523 4.2 36.9 1.0
OD1 B:ASN523 4.4 32.7 1.0

Reference:

S.Nandi, M.Razzaghi, D.Srivastava, M.Dey. Structural Basis For Allosteric Regulation of Pyruvate Kinase M2 By Phosphorylation and Acetylation. J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X
PubMed: 32989054
DOI: 10.1074/JBC.RA120.015800
Page generated: Sat Jul 12 21:21:52 2025

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