Chlorine in PDB 6wxc: Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil

All present enzymatic activity of Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

The structure of Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil, PDB code: 6wxc was solved by Y.Kim, N.Maltseva, R.Jedrzejczak, M.Endres, C.Chang, K.Michalska, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.45 / 1.85
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	150.863, 150.863, 111.703, 90.00, 90.00, 120.00
R / Rfree (%)	17.1 / 19.4

The binding sites of Chlorine atom in the Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil (pdb code 6wxc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil, PDB code: 6wxc:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:48.2 occ:0.86 CL1 A:CMU401 0.0 48.2 0.9 C2 A:CMU401 1.7 43.2 0.9 C15 A:CMU401 2.7 39.3 0.9 C3 A:CMU401 2.7 38.2 0.9 O16 A:CMU401 3.0 39.2 0.9 C4 A:CMU401 3.1 39.3 0.9 NZ A:LYS345 3.3 61.7 1.0 C6 A:CMU401 3.3 47.0 0.9 O A:HOH703 3.4 51.0 1.0 N5 A:CMU401 3.5 43.6 0.9 OH A:TYR343 3.7 44.3 1.0 CE1 A:TYR343 3.8 31.6 1.0 N14 A:CMU401 4.0 34.4 0.9 N11 A:CMU401 4.0 33.0 0.9 CZ A:TYR343 4.0 40.3 1.0 O A:HOH642 4.2 44.6 1.0 C7 A:CMU401 4.4 50.7 0.9 C12 A:CMU401 4.5 27.0 0.9 CE A:LYS345 4.7 60.9 1.0 CD1 A:TYR343 4.8 33.9 1.0 C9 A:CMU401 4.8 45.9 0.9

Chlorine binding site 2 out of 2 in the Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl401 b:61.2 occ:0.85 CL1 B:CMU401 0.0 61.2 0.8 C2 B:CMU401 1.7 52.3 0.8 C3 B:CMU401 2.7 45.5 0.8 C15 B:CMU401 2.7 46.5 0.8 O16 B:CMU401 3.0 46.2 0.8 C4 B:CMU401 3.1 49.5 0.8 C6 B:CMU401 3.4 59.9 0.8 OH B:TYR343 3.4 50.3 1.0 O B:HOH520 3.4 57.0 1.0 CE1 B:TYR343 3.6 45.0 1.0 N5 B:CMU401 3.6 56.1 0.8 CZ B:TYR343 3.7 47.6 1.0 NZ B:LYS345 3.8 67.7 1.0 N11 B:CMU401 4.0 41.4 0.8 N14 B:CMU401 4.0 38.2 0.8 C12 B:CMU401 4.5 33.1 0.8 O B:HOH628 4.5 53.4 1.0 CD1 B:TYR343 4.6 43.3 1.0 C7 B:CMU401 4.6 64.8 0.8 CE2 B:TYR343 4.8 47.7 1.0 C9 B:CMU401 4.9 61.0 0.8 CE B:LYS345 4.9 65.0 1.0

Y.Kim, N.Maltseva, R.Jedrzejczak, M.Endres, C.Chang, K.Michalska, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of NSP15 Endoribonuclease From Sars Cov-2 in the Complex with Potential Refurbishing Drug Tipiracil To Be Published.