Chlorine in PDB 6ylv: Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog

The structure of Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog, PDB code: 6ylv was solved by D.Kubacka, R.Wojcik, M.R.Baranowski, J.Kowalska, J.Jemielity, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.19 / 2.66
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	38.350, 38.390, 148.080, 85.28, 88.42, 77.23
R / Rfree (%)	20.1 / 25.5

The binding sites of Chlorine atom in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog (pdb code 6ylv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog, PDB code: 6ylv:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl300 b:71.1 occ:0.42 CL1 A:OYW300 0.0 71.1 0.4 CL1 A:OYW300 0.0 71.9 0.6 C15 A:OYW300 1.7 66.1 0.4 C15 A:OYW300 1.7 66.1 0.6 OG A:SER92 2.6 43.5 1.0 O A:HOH447 2.7 35.8 1.0 C17 A:OYW300 2.7 63.9 0.4 C13 A:OYW300 2.7 64.4 0.6 C13 A:OYW300 2.7 64.5 0.4 C17 A:OYW300 2.7 63.9 0.6 CB A:SER92 3.7 29.2 1.0 CG1 A:VAL153 3.7 20.2 1.0 OD1 A:ASP90 3.8 51.0 1.0 CB A:ASP90 3.9 33.7 1.0 C16 A:OYW300 4.0 62.9 0.4 C14 A:OYW300 4.0 64.3 0.6 C14 A:OYW300 4.0 64.1 0.4 C16 A:OYW300 4.0 62.9 0.6 CG2 A:VAL153 4.1 20.1 1.0 CG A:ASP90 4.4 43.5 1.0 CB A:PRO100 4.4 52.5 1.0 C12 A:OYW300 4.5 62.9 0.4 C12 A:OYW300 4.5 63.1 0.6 CB A:VAL153 4.5 19.6 1.0 CD2 A:LEU60 4.5 35.1 1.0 CA A:SER92 4.8 23.5 1.0 O A:TYR91 4.9 30.4 1.0 CB A:PHE48 4.9 20.4 1.0 CZ2 A:TRP56 4.9 24.2 1.0 CG A:PRO100 5.0 53.3 1.0

Chlorine binding site 2 out of 6 in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl300 b:71.9 occ:0.58 CL1 A:OYW300 0.0 71.9 0.6 CL1 A:OYW300 0.0 71.1 0.4 C15 A:OYW300 1.7 66.1 0.4 C15 A:OYW300 1.7 66.1 0.6 OG A:SER92 2.6 43.5 1.0 C17 A:OYW300 2.7 63.9 0.4 O A:HOH447 2.7 35.8 1.0 C17 A:OYW300 2.7 63.9 0.6 C13 A:OYW300 2.7 64.4 0.6 C13 A:OYW300 2.7 64.5 0.4 CB A:SER92 3.7 29.2 1.0 CG1 A:VAL153 3.7 20.2 1.0 OD1 A:ASP90 3.9 51.0 1.0 CB A:ASP90 3.9 33.7 1.0 C16 A:OYW300 4.0 62.9 0.4 C16 A:OYW300 4.0 62.9 0.6 C14 A:OYW300 4.0 64.3 0.6 C14 A:OYW300 4.0 64.1 0.4 CG2 A:VAL153 4.1 20.1 1.0 CB A:PRO100 4.4 52.5 1.0 CG A:ASP90 4.4 43.5 1.0 C12 A:OYW300 4.5 62.9 0.4 C12 A:OYW300 4.5 63.1 0.6 CD2 A:LEU60 4.5 35.1 1.0 CB A:VAL153 4.6 19.6 1.0 CA A:SER92 4.8 23.5 1.0 CB A:PHE48 4.9 20.4 1.0 CZ2 A:TRP56 4.9 24.2 1.0 O A:TYR91 4.9 30.4 1.0 CG A:PRO100 4.9 53.3 1.0 O A:PRO100 5.0 45.3 1.0

Chlorine binding site 3 out of 6 in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl300 b:46.4 occ:0.41 CL1 B:OYW300 0.0 46.4 0.4 CL1 B:OYW300 0.0 46.5 0.6 C15 B:OYW300 1.7 43.4 0.6 C15 B:OYW300 1.7 43.8 0.4 OG B:SER92 2.6 33.6 1.0 C13 B:OYW300 2.7 46.8 0.6 O B:HOH445 2.7 29.3 1.0 C17 B:OYW300 2.7 42.3 0.6 C13 B:OYW300 2.7 46.5 0.4 C17 B:OYW300 2.7 42.5 0.4 CB B:SER92 3.7 23.4 1.0 CB B:ASP90 3.8 28.6 1.0 CD2 B:LEU60 3.9 21.6 1.0 C14 B:OYW300 4.0 48.1 0.6 C16 B:OYW300 4.0 42.6 0.6 C14 B:OYW300 4.0 47.6 0.4 C16 B:OYW300 4.0 42.8 0.4 OD2 B:ASP90 4.0 52.0 1.0 CG1 B:VAL153 4.2 15.8 1.0 CG B:ASP90 4.4 46.1 1.0 CB B:PHE48 4.4 21.4 1.0 CG2 B:VAL153 4.5 23.6 1.0 C12 B:OYW300 4.5 44.6 0.6 C12 B:OYW300 4.5 44.2 0.4 CB B:PRO100 4.7 46.4 1.0 CA B:SER92 4.8 23.5 1.0 O B:TYR91 4.8 21.5 1.0 N B:SER92 4.9 28.9 1.0 C B:TYR91 4.9 31.7 1.0 CZ2 B:TRP56 5.0 15.5 1.0 CB B:VAL153 5.0 18.0 1.0 CG B:LEU60 5.0 19.8 1.0 O B:PRO100 5.0 31.0 1.0

Chlorine binding site 4 out of 6 in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl300 b:46.5 occ:0.59 CL1 B:OYW300 0.0 46.5 0.6 CL1 B:OYW300 0.0 46.4 0.4 C15 B:OYW300 1.7 43.4 0.6 C15 B:OYW300 1.7 43.8 0.4 OG B:SER92 2.7 33.6 1.0 O B:HOH445 2.7 29.3 1.0 C13 B:OYW300 2.7 46.8 0.6 C17 B:OYW300 2.7 42.3 0.6 C17 B:OYW300 2.7 42.5 0.4 C13 B:OYW300 2.7 46.5 0.4 CB B:SER92 3.7 23.4 1.0 CB B:ASP90 3.8 28.6 1.0 CD2 B:LEU60 3.9 21.6 1.0 C14 B:OYW300 4.0 48.1 0.6 C16 B:OYW300 4.0 42.6 0.6 C14 B:OYW300 4.0 47.6 0.4 C16 B:OYW300 4.0 42.8 0.4 OD2 B:ASP90 4.0 52.0 1.0 CG1 B:VAL153 4.2 15.8 1.0 CB B:PHE48 4.4 21.4 1.0 CG B:ASP90 4.4 46.1 1.0 C12 B:OYW300 4.5 44.6 0.6 C12 B:OYW300 4.5 44.2 0.4 CG2 B:VAL153 4.5 23.6 1.0 CB B:PRO100 4.6 46.4 1.0 CA B:SER92 4.8 23.5 1.0 O B:TYR91 4.8 21.5 1.0 N B:SER92 4.9 28.9 1.0 C B:TYR91 4.9 31.7 1.0 CG B:LEU60 4.9 19.8 1.0 CZ2 B:TRP56 4.9 15.5 1.0 O B:PRO100 5.0 31.0 1.0

Chlorine binding site 5 out of 6 in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl300 b:69.3 occ:1.00 CL1 C:OYW300 0.0 69.3 1.0 C15 C:OYW300 1.7 67.4 1.0 OG C:SER92 2.7 48.4 1.0 C13 C:OYW300 2.7 65.5 1.0 C17 C:OYW300 2.7 67.3 1.0 CB C:ASP90 3.6 54.0 1.0 CB C:SER92 3.7 36.4 1.0 CD2 C:LEU60 4.0 38.2 1.0 C14 C:OYW300 4.0 68.7 1.0 C16 C:OYW300 4.0 67.1 1.0 OD1 C:ASP90 4.1 63.0 1.0 CB C:PHE48 4.2 38.4 1.0 CG C:ASP90 4.3 61.9 1.0 CG1 C:VAL153 4.4 51.2 1.0 C12 C:OYW300 4.5 71.4 1.0 CG2 C:VAL153 4.7 41.5 1.0 CA C:SER92 4.7 36.1 1.0 O C:TYR91 4.8 46.0 1.0 N C:SER92 4.8 38.6 1.0 C C:TYR91 4.8 42.8 1.0 CA C:ASP90 4.9 46.7 1.0 C C:ASP90 4.9 50.3 1.0 CB C:PRO100 4.9 46.2 1.0 CG C:PHE48 5.0 52.5 1.0

Chlorine binding site 6 out of 6 in the Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Translation Initiation Factor 4E in Complex with 4-Cl-BN7GPPPG Mrna 5' Cap Analog within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl300 b:71.0 occ:1.00 CL1 D:OYW300 0.0 71.0 1.0 C15 D:OYW300 1.7 70.9 1.0 O D:HOH425 2.5 73.8 1.0 C13 D:OYW300 2.7 70.5 1.0 C17 D:OYW300 2.7 67.4 1.0 OG D:SER92 2.8 57.4 1.0 CB D:SER92 3.6 39.7 1.0 CB D:ASP90 3.7 54.6 1.0 CD1 D:LEU60 3.8 49.9 1.0 C14 D:OYW300 4.0 71.5 1.0 C16 D:OYW300 4.0 66.5 1.0 CB D:PHE48 4.1 57.9 1.0 CG D:ASP90 4.4 69.8 1.0 C12 D:OYW300 4.5 71.4 1.0 CG1 D:VAL153 4.7 37.3 1.0 CA D:SER92 4.7 35.8 1.0 N D:SER92 4.7 36.7 1.0 C D:TYR91 4.8 44.0 1.0 OD1 D:ASP90 4.8 70.7 1.0 O D:TYR91 4.8 30.7 1.0 CB D:PRO100 4.8 45.1 1.0 C D:ASP90 4.8 44.7 1.0 CD2 D:LEU60 4.9 36.1 1.0 CA D:ASP90 4.9 45.5 1.0 CG D:PHE48 4.9 66.4 1.0 CG D:LEU60 4.9 46.7 1.0

J.Jemielity, D.Kubacka, R.Wojcik, M.R.Baranowski, J.Kowalska, J.Jemielity. N/A N/A.