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Chlorine in PDB 6za4: M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate
Enzymatic activity of M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate
All present enzymatic activity of M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate:
4.2.99.21; 5.4.4.2; 5.4.99.5;
4.2.99.21; 5.4.4.2; 5.4.99.5;
Protein crystallography data
The structure of M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate, PDB code: 6za4
was solved by
M.Mori,
S.Villa,
F.Meneghetti,
M.Bellinzoni,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 94.89 / 2.09 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 88.336, 111.687, 94.998, 90.00, 92.67, 90.00 |
| R / Rfree (%) | 20.8 / 24 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate
(pdb code 6za4). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate, PDB code: 6za4:
In total only one binding site of Chlorine was determined in the M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate, PDB code: 6za4:
Chlorine binding site 1 out of 1 in 6za4
Go back to
Chlorine Binding Sites List in 6za4
Chlorine binding site 1 out
of 1 in the M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of M. Tuberculosis Salicylate Synthase Mbti in Complex with 5-(3- Cyanophenyl)Furan-2-Carboxylate within 5.0Å range:
|
Reference:
M.Mori,
G.Stelitano,
A.Gelain,
E.Pini,
L.R.Chiarelli,
J.C.Sammartino,
G.Poli,
T.Tuccinardi,
G.Beretta,
A.Porta,
M.Bellinzoni,
S.Villa,
F.Meneghetti.
Shedding X-Ray Light on the Role of Magnesium in the Activity Ofmycobacterium Tuberculosissalicylate Synthase (Mbti) For Drug Design. J.Med.Chem. V. 63 7066 2020.
ISSN: ISSN 0022-2623
PubMed: 32530281
DOI: 10.1021/ACS.JMEDCHEM.0C00373
Page generated: Mon Jul 29 18:00:42 2024
ISSN: ISSN 0022-2623
PubMed: 32530281
DOI: 10.1021/ACS.JMEDCHEM.0C00373
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