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Chlorine in PDB 6zft: Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68

Enzymatic activity of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68

All present enzymatic activity of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68:
7.1.1.8;

Protein crystallography data

The structure of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68, PDB code: 6zft was solved by K.Amporndanai, P.M.O'neill, W.D.Hong, R.K.Amewu, C.Pidathala, N.G.Berry, G.A.Biagini, S.C.Leung, S.S.Hasnain, S.V.Antonyuk, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 60.92 / 3.30
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 212.36, 212.36, 345.914, 90, 90, 120
R / Rfree (%) 21.4 / 24.4

Other elements in 6zft:

The structure of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68 also contains other interesting chemical elements:

Iron (Fe) 5 atoms
Fluorine (F) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68 (pdb code 6zft). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68, PDB code: 6zft:

Chlorine binding site 1 out of 1 in 6zft

Go back to Chlorine Binding Sites List in 6zft
Chlorine binding site 1 out of 1 in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Ck-2-68 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl404

b:96.1
occ:1.00
CL C:JHB404 0.0 96.1 1.0
C2 C:JHB404 1.8 93.9 1.0
C1 C:JHB404 2.8 92.1 1.0
C3 C:JHB404 2.8 93.7 1.0
OG C:SER205 2.8 73.6 1.0
CB C:SER205 3.6 73.6 1.0
CD1 C:ILE27 3.9 74.5 1.0
C C:JHB404 4.1 92.0 1.0
C4 C:JHB404 4.1 93.7 1.0
O C:HOH501 4.1 73.7 1.0
CB C:ALA23 4.3 74.0 1.0
CD C:PRO24 4.5 73.9 1.0
C5 C:JHB404 4.6 93.0 1.0
CD1 C:TRP31 4.7 74.2 1.0
CG1 C:ILE27 4.8 74.6 1.0
CG2 C:ILE27 4.9 74.3 1.0
CA C:ALA23 4.9 73.9 1.0
CD2 C:LEU21 4.9 73.5 1.0
CE1 C:PHE220 5.0 74.2 1.0

Reference:

K.Amporndanai, P.M.O'neill, W.D.Hong, R.K.Amewu, C.Pidathala, N.Berry, G.A.Biangini, S.C.Leung, S.S.Hasnain, S.V.Antonyuk. Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome BC1 Complex For the Development of Next Generation Quinolone Antimalarials To Be Published.
Page generated: Mon Jul 29 18:03:37 2024

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