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Chlorine in PDB 7a2a: Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001
Enzymatic activity of Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001
All present enzymatic activity of Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001, PDB code: 7a2a
was solved by
J.Niggenaber,
M.P.Mueller,
D.Rauh,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.84 / 1.90 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 75.180, 83.730, 92.340, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.4 / 21.7 |
Other elements in 7a2a:
The structure of Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001 also contains other interesting chemical elements:
| Fluorine | (F) | 2 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001
(pdb code 7a2a). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001, PDB code: 7a2a:
In total only one binding site of Chlorine was determined in the Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001, PDB code: 7a2a:
Chlorine binding site 1 out of 1 in 7a2a
Go back to
Chlorine Binding Sites List in 7a2a
Chlorine binding site 1 out
of 1 in the Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Egfr-T790M/V948R in Complex with Spebrutinib and EAI001 within 5.0Å range:
|
Reference:
J.Niggenaber,
L.Heyden,
T.Grabe,
M.P.Mueller,
J.Lategahn,
D.Rauh.
Complex Crystal Structures of Egfr with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands Acs Med.Chem.Lett. 2020.
ISSN: ISSN 1948-5875
DOI: 10.1021/ACSMEDCHEMLETT.0C00472
Page generated: Mon Jul 29 18:18:47 2024
ISSN: ISSN 1948-5875
DOI: 10.1021/ACSMEDCHEMLETT.0C00472
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