Chlorine in PDB 7b16: TRPC4 in Complex with Inhibitor Gfb-9289

The structure of TRPC4 in Complex with Inhibitor Gfb-9289 also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

The binding sites of Chlorine atom in the TRPC4 in Complex with Inhibitor Gfb-9289 (pdb code 7b16). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the TRPC4 in Complex with Inhibitor Gfb-9289, PDB code: 7b16:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:32.1 occ:1.00 CL1 A:SKQ1001 0.0 32.1 1.0 C06 A:SKQ1001 1.9 32.1 1.0 C13 A:SKQ1001 2.9 32.1 1.0 C05 A:SKQ1001 3.0 32.1 1.0 C08 A:SKQ1001 3.0 32.1 1.0 O12 A:SKQ1001 3.2 32.1 1.0 CE1 A:TYR373 3.2 26.3 1.0 N04 A:SKQ1001 3.3 32.1 1.0 C14 A:SKQ1001 3.5 32.1 1.0 CD1 A:TYR373 3.8 26.3 1.0 OG A:SER488 3.8 20.2 1.0 O A:SER488 4.1 20.2 1.0 CZ A:TYR373 4.1 26.3 1.0 CE2 A:PHE413 4.2 39.7 1.0 OH A:TYR373 4.3 26.3 1.0 C11 A:SKQ1001 4.4 32.1 1.0 N09 A:SKQ1001 4.4 32.1 1.0 CG A:ARG491 4.4 26.7 1.0 CZ A:PHE413 4.4 39.7 1.0 CB A:ARG491 4.4 26.7 1.0 CA A:SER488 4.5 20.2 1.0 SD A:MET441 4.5 33.9 1.0 CB A:SER488 4.6 20.2 1.0 C03 A:SKQ1001 4.6 32.1 1.0 CD2 A:PHE413 4.7 39.7 1.0 CE2 A:PHE376 4.7 26.8 1.0 C A:SER488 4.8 20.2 1.0 CD2 A:PHE376 4.9 26.8 1.0 N10 A:SKQ1001 5.0 32.1 1.0 N15 A:SKQ1001 5.0 32.1 1.0

Chlorine binding site 2 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1002 b:32.5 occ:1.00 CL1 B:SKQ1002 0.0 32.5 1.0 C06 B:SKQ1002 1.9 32.5 1.0 C13 B:SKQ1002 2.9 32.5 1.0 C05 B:SKQ1002 3.0 32.5 1.0 C08 B:SKQ1002 3.0 32.5 1.0 CE1 B:TYR373 3.2 26.4 1.0 O12 B:SKQ1002 3.2 32.5 1.0 N04 B:SKQ1002 3.3 32.5 1.0 C14 B:SKQ1002 3.5 32.5 1.0 CD1 B:TYR373 3.7 26.4 1.0 OG B:SER488 3.8 20.3 1.0 O B:SER488 4.1 20.3 1.0 CZ B:TYR373 4.1 26.4 1.0 CE2 B:PHE413 4.2 39.9 1.0 OH B:TYR373 4.3 26.4 1.0 C11 B:SKQ1002 4.4 32.5 1.0 CZ B:PHE413 4.4 39.9 1.0 N09 B:SKQ1002 4.4 32.5 1.0 CG B:ARG491 4.4 26.9 1.0 CB B:ARG491 4.4 26.9 1.0 CA B:SER488 4.5 20.3 1.0 SD B:MET441 4.5 34.2 1.0 CB B:SER488 4.6 20.3 1.0 C03 B:SKQ1002 4.6 32.5 1.0 CD2 B:PHE413 4.7 39.9 1.0 CE2 B:PHE376 4.7 26.9 1.0 C B:SER488 4.8 20.3 1.0 CD2 B:PHE376 4.9 26.9 1.0 N10 B:SKQ1002 5.0 32.5 1.0 N15 B:SKQ1002 5.0 32.5 1.0

Chlorine binding site 3 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1002 b:32.7 occ:1.00 CL1 C:SKQ1002 0.0 32.7 1.0 C06 C:SKQ1002 1.9 32.7 1.0 C13 C:SKQ1002 2.9 32.7 1.0 C05 C:SKQ1002 3.0 32.7 1.0 C08 C:SKQ1002 3.0 32.7 1.0 CE1 C:TYR373 3.2 26.5 1.0 O12 C:SKQ1002 3.2 32.7 1.0 N04 C:SKQ1002 3.3 32.7 1.0 C14 C:SKQ1002 3.5 32.7 1.0 CD1 C:TYR373 3.7 26.5 1.0 OG C:SER488 3.8 20.3 1.0 O C:SER488 4.1 20.3 1.0 CZ C:TYR373 4.1 26.5 1.0 CE2 C:PHE413 4.2 40.1 1.0 OH C:TYR373 4.3 26.5 1.0 C11 C:SKQ1002 4.4 32.7 1.0 N09 C:SKQ1002 4.4 32.7 1.0 CG C:ARG491 4.4 26.9 1.0 CZ C:PHE413 4.4 40.1 1.0 CB C:ARG491 4.4 26.9 1.0 CA C:SER488 4.5 20.3 1.0 SD C:MET441 4.5 34.5 1.0 CB C:SER488 4.6 20.3 1.0 C03 C:SKQ1002 4.6 32.7 1.0 CD2 C:PHE413 4.7 40.1 1.0 CE2 C:PHE376 4.7 26.9 1.0 C C:SER488 4.8 20.3 1.0 CD2 C:PHE376 4.9 26.9 1.0 N10 C:SKQ1002 5.0 32.7 1.0 N15 C:SKQ1002 5.0 32.7 1.0

Chlorine binding site 4 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-9289


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-9289 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1002 b:32.2 occ:1.00 CL1 D:SKQ1002 0.0 32.2 1.0 C06 D:SKQ1002 1.9 32.2 1.0 C13 D:SKQ1002 2.9 32.2 1.0 C05 D:SKQ1002 3.0 32.2 1.0 C08 D:SKQ1002 3.0 32.2 1.0 CE1 D:TYR373 3.2 26.5 1.0 O12 D:SKQ1002 3.2 32.2 1.0 N04 D:SKQ1002 3.3 32.2 1.0 C14 D:SKQ1002 3.5 32.2 1.0 CD1 D:TYR373 3.7 26.5 1.0 OG D:SER488 3.8 20.3 1.0 O D:SER488 4.1 20.3 1.0 CZ D:TYR373 4.1 26.5 1.0 CE2 D:PHE413 4.2 39.9 1.0 OH D:TYR373 4.3 26.5 1.0 C11 D:SKQ1002 4.4 32.2 1.0 N09 D:SKQ1002 4.4 32.2 1.0 CZ D:PHE413 4.4 39.9 1.0 CG D:ARG491 4.4 26.7 1.0 CB D:ARG491 4.4 26.7 1.0 CA D:SER488 4.5 20.3 1.0 SD D:MET441 4.5 34.2 1.0 CB D:SER488 4.6 20.3 1.0 C03 D:SKQ1002 4.6 32.2 1.0 CD2 D:PHE413 4.7 39.9 1.0 CE2 D:PHE376 4.7 26.9 1.0 C D:SER488 4.8 20.3 1.0 CD2 D:PHE376 4.9 26.9 1.0 N10 D:SKQ1002 5.0 32.2 1.0 N15 D:SKQ1002 5.0 32.2 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603