Chlorine in PDB 7evv: Co-Crystal Structure of Toxoplasma Gondii Prolyl Trna Synthetase (Tgprs) in Complex with JE6 and L-Pro

The structure of Co-Crystal Structure of Toxoplasma Gondii Prolyl Trna Synthetase (Tgprs) in Complex with JE6 and L-Pro, PDB code: 7evv was solved by N.Malhotra, S.Mishra, Y.Manickam, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.52 / 1.70
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	111.35, 75.2, 74.74, 90, 110.74, 90
R / Rfree (%)	15.3 / 18.1

The binding sites of Chlorine atom in the Co-Crystal Structure of Toxoplasma Gondii Prolyl Trna Synthetase (Tgprs) in Complex with JE6 and L-Pro (pdb code 7evv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Co-Crystal Structure of Toxoplasma Gondii Prolyl Trna Synthetase (Tgprs) in Complex with JE6 and L-Pro, PDB code: 7evv:

Chlorine binding site 1 out of 1 in the Co-Crystal Structure of Toxoplasma Gondii Prolyl Trna Synthetase (Tgprs) in Complex with JE6 and L-Pro


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Co-Crystal Structure of Toxoplasma Gondii Prolyl Trna Synthetase (Tgprs) in Complex with JE6 and L-Pro within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl903 b:77.4 occ:1.00 OE1 A:GLN379 4.7 34.5 1.0 CD A:GLN379 4.9 32.2 1.0

Y.Manickam, N.Malhotra, S.Mishra, P.Babbar, A.Dusane, B.Laleu, V.Bellini, M.A.Hakimi, A.Bougdour, A.Sharma. Double Drugging of Prolyl-Trna Synthetase Provides A New Paradigm For Anti-Infective Drug Development. Plos Pathog. V. 18 10363 2022.
ISSN: ESSN 1553-7374
PubMed: 35333915
DOI: 10.1371/JOURNAL.PPAT.1010363