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PDB 7epi-7f6k »
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Chlorine in PDB 7ezf: Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase
Enzymatic activity of Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase
All present enzymatic activity of Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase:
3.1.3.11;
3.1.3.11;
Protein crystallography data
The structure of Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase, PDB code: 7ezf
was solved by
X.Y.Wang,
J.Zhou,
B.L.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.67 / 2.76 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 67.076, 143.329, 73.491, 90, 108.14, 90 |
| R / Rfree (%) | 19.2 / 23.6 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase
(pdb code 7ezf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase, PDB code: 7ezf:
Jump to Chlorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Chlorine where determined in the Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase, PDB code: 7ezf:
Jump to Chlorine binding site number: 1; 2; 3; 4;
Chlorine binding site 1 out of 4 in 7ezf
Go back to
Chlorine Binding Sites List in 7ezf
Chlorine binding site 1 out
of 4 in the Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase within 5.0Å range:
|
Chlorine binding site 2 out of 4 in 7ezf
Go back to
Chlorine Binding Sites List in 7ezf
Chlorine binding site 2 out
of 4 in the Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase within 5.0Å range:
|
Chlorine binding site 3 out of 4 in 7ezf
Go back to
Chlorine Binding Sites List in 7ezf
Chlorine binding site 3 out
of 4 in the Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase within 5.0Å range:
|
Chlorine binding site 4 out of 4 in 7ezf
Go back to
Chlorine Binding Sites List in 7ezf
Chlorine binding site 4 out
of 4 in the Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Indole-2-Carboxylic Acid Derivatives As Allosteric Inhibitors of Fructose-1,6-Bisphosphatase within 5.0Å range:
|
Reference:
X.Wang,
R.Zhao,
W.Ji,
J.Zhou,
Q.Liu,
L.Zhao,
Z.Shen,
S.Liu,
B.Xu.
Discovery of Novel Indole Derivatives As Fructose-1,6-Bisphosphatase Inhibitors and X-Ray Cocrystal Structures Analysis. Acs Med.Chem.Lett. V. 13 118 2022.
ISSN: ISSN 1948-5875
PubMed: 35059131
DOI: 10.1021/ACSMEDCHEMLETT.1C00613
Page generated: Sun Jul 13 00:31:02 2025
ISSN: ISSN 1948-5875
PubMed: 35059131
DOI: 10.1021/ACSMEDCHEMLETT.1C00613
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