Chlorine »
PDB 7gmh-7gnk »
7gnb »
Chlorine in PDB 7gnb: Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468)
Enzymatic activity of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468)
All present enzymatic activity of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468):
3.4.22.69;
3.4.22.69;
Protein crystallography data
The structure of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468), PDB code: 7gnb
was solved by
D.Fearon,
A.Aimon,
J.C.Aschenbrenner,
B.H.Balcomb,
F.K.R.Bertram,
J.Brandao-Neto,
A.Dias,
A.Douangamath,
L.Dunnett,
A.S.Godoy,
T.J.Gorrie-Stone,
L.Koekemoer,
T.Krojer,
R.M.Lithgo,
P.Lukacik,
P.G.Marples,
H.Mikolajek,
E.Nelson,
C.D.Owen,
A.J.Powell,
V.L.Rangel,
R.Skyner,
C.M.Strain-Damerell,
W.Thompson,
C.W.E.Tomlinson,
C.Wild,
M.A.Walsh,
F.Von Delft,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 32.88 / 1.67 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 68.021, 101.103, 104.322, 90, 90, 90 |
| R / Rfree (%) | 21 / 23.9 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468)
(pdb code 7gnb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468), PDB code: 7gnb:
Jump to Chlorine binding site number: 1; 2; 3;
In total 3 binding sites of Chlorine where determined in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468), PDB code: 7gnb:
Jump to Chlorine binding site number: 1; 2; 3;
Chlorine binding site 1 out of 3 in 7gnb
Go back to
Chlorine Binding Sites List in 7gnb
Chlorine binding site 1 out
of 3 in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468) within 5.0Å range:
|
Chlorine binding site 2 out of 3 in 7gnb
Go back to
Chlorine Binding Sites List in 7gnb
Chlorine binding site 2 out
of 3 in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468) within 5.0Å range:
|
Chlorine binding site 3 out of 3 in 7gnb
Go back to
Chlorine Binding Sites List in 7gnb
Chlorine binding site 3 out
of 3 in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Edg-Med-EE636701-1 (Mpro-P2468) within 5.0Å range:
|
Reference:
M.L.Boby,
D.Fearon,
M.Ferla,
M.Filep,
L.Koekemoer,
M.C.Robinson,
The Covid Moonshot Consortium,
J.D.Chodera,
A.A.Lee,
N.London,
A.Von Delft,
F.Von Delft.
Open Science Discovery of Potent Noncovalent Sars-Cov-2 Main Protease Inhibitors Science 2023.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.ABO7201
Page generated: Sun Jul 13 02:00:00 2025
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.ABO7201
Last articles
Mn in 8VGZMn in 8VAG
Mn in 8VFB
Mn in 8VFA
Mn in 8VA9
Mn in 8V9Q
Mn in 8V7K
Mn in 8V7F
Mn in 8UWB
Mn in 8UW0
