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Chlorine in PDB 7jnt: Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor
Enzymatic activity of Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor
All present enzymatic activity of Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor, PDB code: 7jnt
was solved by
J.K.Muckelbauer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 98.44 / 2.21 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 93.617, 100.992, 102.888, 83.11, 73.53, 78.38 |
| R / Rfree (%) | 21.1 / 24.9 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor
(pdb code 7jnt). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor, PDB code: 7jnt:
Jump to Chlorine binding site number: 1; 2; 3;
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor, PDB code: 7jnt:
Jump to Chlorine binding site number: 1; 2; 3;
Chlorine binding site 1 out of 3 in 7jnt
Go back to
Chlorine Binding Sites List in 7jnt
Chlorine binding site 1 out
of 3 in the Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor within 5.0Å range:
|
Chlorine binding site 2 out of 3 in 7jnt
Go back to
Chlorine Binding Sites List in 7jnt
Chlorine binding site 2 out
of 3 in the Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor within 5.0Å range:
|
Chlorine binding site 3 out of 3 in 7jnt
Go back to
Chlorine Binding Sites List in 7jnt
Chlorine binding site 3 out
of 3 in the Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of Rho-Associated Protein Kinase 2 (ROCK2) in Complex with A Potent and Selective Dual Rock Inhibitor within 5.0Å range:
|
Reference:
Z.Hu,
C.Wang,
D.Sitkoff,
N.L.Cheadle,
S.Xu,
J.K.Muckelbauer,
L.P.Adam,
R.R.Wexler,
M.L.Quan.
Identification of 5H-Chromeno[3,4-C]Pyridine and 6H-Isochromeno[3,4-C]Pyridine Derivatives As Potent and Selective Dual Rock Inhibitors. Bioorg.Med.Chem.Lett. V. 30 27474 2020.
ISSN: ESSN 1464-3405
PubMed: 32805407
DOI: 10.1016/J.BMCL.2020.127474
Page generated: Sun Jul 13 03:02:10 2025
ISSN: ESSN 1464-3405
PubMed: 32805407
DOI: 10.1016/J.BMCL.2020.127474
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